Institute for Genomic Health, SUNY Downstate Medical Center, Brooklyn, NY, USA; Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Institute for Genomic Health, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Psychiatry Res. 2020 Jul;289:112962. doi: 10.1016/j.psychres.2020.112962. Epub 2020 May 6.
The present study examined whether or not there are differential rates of traumatic event exposure and presumed Post-Traumatic Stress Disorder (PTSD) between individuals with OCD without comorbid presumed BDD (OCD-Non-BDD) and individuals with OCD with comorbid presumed BDD (OCD+BDD) within a large cohort of OCD participants (N = 605). Individuals in the OCD+BDD group had significantly higher rates of endorsing at least one lifetime traumatic event and presumed PTSD than individuals with OCD-Non-BDD. Additionally, individuals in the OCD+BDD group with comorbid presumed PTSD had significantly higher rates of major depressive disorder (MDD) and presumed panic disorder (PD). A logistic regression analysis revealed that presumed PTSD significantly predicted the presence of BDD symptoms among individuals who experienced at least one lifetime traumatic event in our sample. These findings suggest that individuals in the OCD+BDD group were more likely to have experienced a traumatic event in their lives, to experience presumed PTSD, and to have MDD and presumed PD than individuals in the OCD-Non-BDD group. Clinical implications and possible mechanistic pathways from trauma exposure to OCD and BDD symptomatology are discussed.
本研究旨在探讨在一个大型强迫症患者队列中（N=605），是否存在强迫症伴或不伴假定躯体变形障碍（OCD+BDD）个体之间创伤性事件暴露和假定创伤后应激障碍（PTSD）的发生率存在差异。与 OCD-Non-BDD 个体相比，OCD+BDD 组的个体报告至少有一种终生创伤性事件和假定 PTSD 的发生率明显更高。此外，患有共病假定 PTSD 的 OCD+BDD 组个体的重度抑郁障碍（MDD）和假定惊恐障碍（PD）的发生率也明显更高。逻辑回归分析显示，在我们的样本中，经历过至少一次终生创伤性事件的个体中，假定 PTSD 显著预测 BDD 症状的存在。这些发现表明，与 OCD-Non-BDD 组个体相比，OCD+BDD 组个体更有可能在其生活中经历创伤性事件、经历假定 PTSD，以及患有 MDD 和假定 PD。讨论了从创伤暴露到 OCD 和 BDD 症状的临床意义和可能的机制途径。
