Centre for Mental Health, Swinburne University of Technology, Advanced Technology Building, Burwood Rd, Hawthorn, Melbourne, VIC 3122, Australia.
School of Psychology, Australian Catholic University, Melbourne, Australia.
Neurosci Biobehav Rev. 2017 Dec;83:83-96. doi: 10.1016/j.neubiorev.2017.10.003. Epub 2017 Oct 7.
There has been an increase in neuroimaging research in body dysmorphic disorder (BDD), yet little is known about the underlying neurobiological basis of the disorder. We aimed to provide a systematic overview of the literature on the neurobiology of BDD. Two reviewers undertook a search of three electronic research databases: PubMed, PsycINFO, and Google Scholar. The search consisted of synonyms commonly associated with BDD and methods to evaluate brain structure, function, and network organisation. Out of an initial yield of 175 articles, 19 fulfilled inclusion criteria and were reviewed. We identified differences in brain activity, structure, and connectivity in BDD participants in frontostriatal, limbic, and visual system regions when compared to healthy control and other clinical groups. We put forth a neurobiological model of BDD pathophysiology that involves wide-spread disorganisation in neural networks involved in cognitive control and the interpretation of visual and emotional information. This review considers how this model might aid in the development of future research and understanding of BDD.
躯体变形障碍（BDD）的神经影像学研究有所增加，但对该障碍的潜在神经生物学基础知之甚少。我们旨在对 BDD 的神经生物学文献进行系统综述。两位审查员对三个电子研究数据库（PubMed、PsycINFO 和 Google Scholar）进行了搜索。搜索包括与 BDD 相关的同义词以及评估大脑结构、功能和网络组织的方法。在最初的 175 篇文章中，有 19 篇符合纳入标准并进行了综述。与健康对照组和其他临床组相比，我们发现 BDD 参与者在前额叶皮质、边缘系统和视觉系统区域的大脑活动、结构和连接存在差异。我们提出了一个 BDD 病理生理学的神经生物学模型，该模型涉及到涉及认知控制和视觉及情绪信息解释的神经网络的广泛紊乱。本综述考虑了该模型如何有助于未来研究和理解 BDD 的发展。
