越南婴幼儿功能性胃肠疾病的流行状况及危险因素。
Prevalence and risk factors of functional gastrointestinal disorders in Vietnamese infants and young children.
机构信息
FrieslandCampina, Amersfoort, The Netherlands.
FrieslandCampina Development Centre AMEA,, 89 Science Park Drive, #02-05 The Rutherford B, Science Park 1, Singapore, 118261, Singapore.
出版信息
BMC Pediatr. 2022 May 27;22(1):315. doi: 10.1186/s12887-022-03378-z.
BACKGROUND
Functional gastrointestinal disorders (FGIDs) are common early in life. The prevalence of FGIDs varies among countries but is unknown in Vietnam. The aim of this study is to assess the prevalence of FGIDs in healthy Vietnamese infants and young children.
METHODS
This was a cross-sectional, observational study involving healthy infants and young children between 0 - 48 months old in Hanoi, Vietnam. A representative total of 1511 subjects completed the validated questionnaire on paediatric FGIDs. Rome IV criteria were used to define FGIDs.
RESULTS
For Vietnamese infants (0-6 months) and young children (7-48 months), the prevalence of having at least one FGID was 10.0% and only 0.6% was having more than one FGID. Infantile regurgitation (9.3%) was the most prevalent FGID among infants 0-6 months of age while all other FGIDs had a low prevalence between 0-2.5%. For young children between 7 - 48 months old, functional constipation was the most common disorder at the rate of 5.6%. Association analysis revealed that the risk of infant regurgitation was significantly lower among infants with exclusively breastfeeding at 2 - 3 months and 3 - 4 months, formula initiation at 0 - 1 months, and higher paternal education level. The prevalence of functional constipation was significantly higher in male subjects, children in families with annual household income between 273,000,000 - 546,999,999 VND (or estimate around 11,800 - 23,800 USD), families with one child only, and formula feeding initiation at 1 - 2 months.
CONCLUSIONS
The prevalence of FGIDs in Vietnamese infants and young children is relatively low compared to the published literature using Rome IV diagnostic criteria. Infantile regurgitation was the most common FGID in Vietnamese infants while functional constipation was most prevalent among Vietnamese young children.
TRIAL REGISTRATION
Netherlands Trial Registry Identifier: NL7286/NTR7495 .
背景
功能性胃肠病（FGIDs）在生命早期很常见。FGIDs 的患病率在各国之间有所不同，但在越南尚不清楚。本研究的目的是评估健康越南婴儿和幼儿 FGIDs 的患病率。
方法
这是一项在越南河内进行的横断面、观察性研究，涉及 0-48 个月的健康婴儿和幼儿。共有 1511 名代表完成了小儿 FGIDs 的验证问卷。罗马 IV 标准用于定义 FGIDs。
结果
对于越南婴儿（0-6 个月）和幼儿（7-48 个月），至少有一种 FGID 的患病率为 10.0%，只有 0.6%的人患有多种 FGID。婴儿反流（9.3%）是 0-6 个月龄婴儿中最常见的 FGID，而其他所有 FGIDs 的患病率均在 0-2.5%之间。对于 7-48 个月的幼儿，功能性便秘是最常见的疾病，患病率为 5.6%。关联分析表明，在 2-3 个月和 3-4 个月时仅进行母乳喂养、0-1 个月时开始配方奶喂养以及父亲受教育程度较高的婴儿，发生婴儿反流的风险明显较低。男性、家庭年收入在 273,000,000-546,999,999 越南盾（或估计约 11,800-23,800 美元）之间、仅育有一个孩子以及 1-2 个月时开始配方奶喂养的儿童，功能性便秘的患病率明显较高。
结论
与使用罗马 IV 诊断标准的已发表文献相比，越南婴儿和幼儿 FGIDs 的患病率相对较低。婴儿反流是越南婴儿中最常见的 FGID，而功能性便秘是越南幼儿中最常见的 FGID。
试验注册
荷兰试验注册处标识符：NL7286/NTR7495。
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