Scarpato Elena, Salvatore Silvia, Romano Claudio, Bruzzese Dario, Ferrara Dante, Inferrera Ramona, Zeevenhooven Judith, Steutel Nina F, Benninga Marc A, Staiano Annamaria
From the Department of Translational Medical Sciences - Section of Pediatrics, University of Naples Federico II, Naples, Italy.
the Department of Pediatrics, Ospedale "F. Del Ponte", University of Insubria, Varese, Italy.
J Pediatr Gastroenterol Nutr. 2023 Feb 1;76(2):e27-e35. doi: 10.1097/MPG.0000000000003653. Epub 2022 Nov 1.
Reports of prevalence of functional gastrointestinal disorders (FGIDs) in infants/toddlers are widely variable. Reasons for this variability are not yet fully understood. The objective of this study is to estimate the prevalence of FGIDs according to Rome IV criteria and to evaluate associated factors, in Italian infants and toddlers.
Subjects aged 0-48 months were enrolled by general pediatricians from 3 Italian regions. Parents or legal guardians were administered questionnaires including information about the child, the family, and GI symptoms according to Rome IV criteria.
Five hundred eight infants aged 0-12 months [mean age 4.4 ± 3.4 months; females (F) 40.9%], and 268 children aged 13-48 months (mean age 30.8 ± 10.7 months; F 44.4%) were included. In infants, prevalence of FGIDs was 21.1%, and the most prevalent FGID was infant colic (9.3%). In toddlers, prevalence of FGIDs was 19.6%, with functional constipation being the most frequent disorder (16.1%). In infants, multivariable analysis found that being older, being the only child, and living in a rural environment were associated with a lower rate of FGIDs. Prevalence was, in contrast, higher in infants fed with formula.
One out of 5 Italian infants and young children is affected by at least 1 FGID. The most frequent FGID in infants is infant colic, while in toddlers this is functional constipation. In infants, prevalence of FGIDs is lower if the subject has no siblings, and in children living in a rural environment, while formula feeding represents a risk factor for FGIDs occurrence.
关于婴幼儿功能性胃肠疾病（FGIDs）患病率的报告差异很大。这种差异的原因尚未完全明确。本研究的目的是根据罗马IV标准估计意大利婴幼儿FGIDs的患病率，并评估相关因素。
来自意大利3个地区的普通儿科医生招募了年龄在0至48个月的受试者。根据罗马IV标准，向父母或法定监护人发放问卷，内容包括孩子、家庭和胃肠道症状的信息。
纳入了508名0至12个月的婴儿[平均年龄4.4±3.4个月；女性占40.9%]，以及268名13至48个月的儿童（平均年龄30.8±10.7个月；女性占44.4%）。在婴儿中，FGIDs的患病率为21.1%，最常见的FGID是婴儿腹绞痛（9.3%）。在幼儿中，FGIDs的患病率为19.6%，功能性便秘是最常见的疾病（16.1%）。在婴儿中，多变量分析发现年龄较大、是独生子女以及生活在农村环境与FGIDs的发生率较低有关。相比之下，用配方奶喂养的婴儿患病率较高。
五分之一的意大利婴幼儿受到至少一种FGID的影响。婴儿中最常见的FGID是婴儿腹绞痛，而幼儿中则是功能性便秘。在婴儿中，如果没有兄弟姐妹，以及生活在农村环境中，FGIDs的患病率较低，而配方奶喂养是FGIDs发生的一个危险因素。
