Schmidt W F, Porter W, Carstensen J T
College of Pharmacy, University of Georgia, Athens 30602.
Pharm Res. 1988 Jun;5(6):391-5. doi: 10.1023/a:1015919913896.
Equations derived from the Clausius-Clapeyron and Prigogine-Defay equations were used to determine the free energy of mixing for diastereoisomers and enantiomers from heats of fusion and transition temperature data. These equations are applied to the thermodynamics of mixing of the six binary equimolar combinations of (1R,2S)-ephedrine, (1S,2R)-ephedrine; and (1R,2R)- and (1S,2S)-pseudoephedrine isomers. The relative equilibrium solubility of the binary mixtures in water is consistent with thermodynamic calculations.
从克劳修斯 - 克拉佩龙方程和普里戈金 - 德法伊方程推导出来的公式，被用于根据熔化热和转变温度数据来确定非对映异构体和对映异构体的混合自由能。这些公式被应用于(1R,2S)-麻黄碱、(1S,2R)-麻黄碱以及(1R,2R)-和(1S,2S)-伪麻黄碱异构体的六种二元等摩尔组合的混合热力学。二元混合物在水中的相对平衡溶解度与热力学计算结果一致。
