University of Edinburgh Centre for Cardiovascular Science, Chancellor's Building, Royal Infirmary of Edinburgh, UK.
University of Edinburgh Centre for Cardiovascular Science, Chancellor's Building, Royal Infirmary of Edinburgh, UK.
Clin Radiol. 2021 Jan;76(1):15-26. doi: 10.1016/j.crad.2020.04.007. Epub 2020 May 21.
Aortic stenosis is the most prevalent valvular heart disease worldwide, and rates are increasing with the growing and more elderly population. Although the precise mechanisms that underpin aortic valve stenosis are incompletely understood, pathological valvular calcification has emerged as a key instigator in mediating the biomechanical stiffening that can lead to symptoms, the need for aortic valve replacement, and death if left untreated. Here, we review the currently understood processes leading to aortic valve calcification, summarise the contemporary imaging assessments of valve calcification, and highlight how these might improve patient care and accelerate our pathological understanding and the development of an effective medical therapy.
主动脉瓣狭窄是全球最常见的瓣膜性心脏病，随着人口的增长和老龄化，其发病率也在不断上升。尽管导致主动脉瓣狭窄的确切机制尚不完全清楚，但病理性瓣膜钙化已成为介导生物力学僵硬的关键因素，这种僵硬可导致出现症状、需要进行主动脉瓣置换以及如果不治疗可能导致死亡。在此，我们回顾了目前已知的导致主动脉瓣钙化的过程，总结了瓣膜钙化的当代影像学评估方法，并强调了这些方法如何改善患者的治疗效果，以及如何加速我们对其病理生理学的理解和开发有效的医学治疗方法。
