选择性抗焦虑药丁螺环酮对大鼠应激性溃疡形成的影响。

The effects of buspirone, a selective anxiolytic, on stress ulcer formation in rats.

作者信息

Sullivan R M, Henke P G, Ray A

机构信息

St. Francis Xavier University, Antigonish, N.S., Canada.

出版信息

Pharmacol Biochem Behav. 1988 Oct;31(2):317-9. doi: 10.1016/0091-3057(88)90352-8.

DOI:10.1016/0091-3057(88)90352-8

PMID:3244709

Abstract

The effects of buspirone hydrochloride were investigated on the formation of cold-immobilization gastric stress ulcers. Low doses significantly attenuated, while higher doses greatly potentiated gastric stress pathology. The dopamine antagonist haloperidol, and the agonist apomorphine respectively, reversed the buspirone effects. The role of dopamine in the expression of buspirone's effects is discussed, although other transmitter systems may mediate some of the actions of buspirone.

摘要

研究了盐酸丁螺环酮对冷束缚应激性胃溃疡形成的影响。低剂量可显著减轻，而高剂量则极大地增强胃应激病变。多巴胺拮抗剂氟哌啶醇和激动剂阿扑吗啡分别逆转了丁螺环酮的作用。尽管其他递质系统可能介导丁螺环酮的一些作用，但仍讨论了多巴胺在丁螺环酮作用表达中的作用。