多巴胺在大鼠胃溃疡形成中的作用。
The role of dopamine in the formation of gastric ulcers in rats.
作者信息
Sikirić P, Geber J, Suchanek E, Ivanović D, Gjuris V, Aleksić J, Reić P, Marović A
出版信息
Eur J Pharmacol. 1985 May 28;112(1):127-8. doi: 10.1016/0014-2999(85)90249-3.
PMID:4018137
Abstract
A single dose of the dopamine agonists L-dopa, bromocriptine or apomorphine produced a protective effect by significantly shortening of the length of stomach ulcerations. A single dose of the dopamine antagonists haloperidol, sulpiride or domperidone potentiated the ulcerogenic effect by extending the length of stomach ulcerations. These results point to the fact that dopamine is involved in the rise and development of experimental stomach ulcers.
摘要
单剂量的多巴胺激动剂左旋多巴、溴隐亭或阿扑吗啡通过显著缩短胃溃疡的长度产生了保护作用。单剂量的多巴胺拮抗剂氟哌啶醇、舒必利或多潘立酮则通过延长胃溃疡的长度增强了致溃疡作用。这些结果表明多巴胺参与了实验性胃溃疡的发生和发展。
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