Hu Gaifeng, Li Juan, Wang Quan, Wang Cui, Wang Yang, Gong Tao, Liu Deping
Beijing Hospital, National Center of Gerontology, No. 1 DaHua Road, Dong Dan, Beijing 100730, China; Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, No. 9 Dongdansantiao, Dongcheng District, Beijing 100730, China.
Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, No. 9 Dongdansantiao, Dongcheng District, Beijing 100730, China; Medical Research & Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, China.
Clin Neurol Neurosurg. 2020 Aug;195:105906. doi: 10.1016/j.clineuro.2020.105906. Epub 2020 May 15.
The relationship between serum uric acid (SUA) and the risk of ischemic stroke (IS) has been fully elucidated in previous studies. Therefore, we further investigated the relationship between SUA levels and the risk of IS.
2195 patients at the Beijing Hospital, between February 2012 and May 2018, were enrolled in our hospital-based cross-sectional study. The patients were divided into an IS group and a (non-IS) control group, based on their medical records. SUA level was measured using the enzymatic uricase method. Univariate and multivariable logistic regression models were used for the analysis.
A total of 300 patients with IS [176 men; age (mean ± SD): 71.38 ± 10.66 years] and 1895 control patients [1060 men; age (mean ± SD): 66.12 ± 12.04 years] were enrolled in this study. IS patients had higher concentrations of SUA, compared with control group patients [6.11 ± 1.92 vs. 5.77 ± 1.62 (mg/dL)]; P = 0.004). We observed a J-shaped association between SUA levels and the risk of IS. Both the univariate and multivariate logistic regression analyses found a significantly elevated risk of IS in the bottom and upper SUA levels both in quartiles and deciles, compared with the intermediate SUA levels.
These results indicate a J-shaped, independent association between SUA levels and the risk of IS in high-risk individuals.
血清尿酸（SUA）与缺血性卒中（IS）风险之间的关系在以往研究中已得到充分阐明。因此，我们进一步研究了SUA水平与IS风险之间的关系。
2012年2月至2018年5月期间在北京医院就诊的2195例患者纳入了我们基于医院的横断面研究。根据病历将患者分为IS组和（非IS）对照组。采用酶促尿酸酶法测定SUA水平。使用单变量和多变量逻辑回归模型进行分析。
本研究共纳入300例IS患者[176例男性；年龄（均值±标准差）：71.38±10.66岁]和1895例对照患者[1060例男性；年龄（均值±标准差）：66.12±12.04岁]。与对照组患者相比，IS患者的SUA浓度更高[6.11±1.92 vs. 5.77±1.62（mg/dL）]；P = 0.004）。我们观察到SUA水平与IS风险之间呈J形关联。单变量和多变量逻辑回归分析均发现，与SUA水平处于中间范围相比，处于四分位数和十分位数的最低和最高SUA水平时，IS风险显著升高。
这些结果表明在高危个体中，SUA水平与IS风险之间存在J形独立关联。
