The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Integr Cancer Ther. 2020 Jan-Dec;19:1534735420922579. doi: 10.1177/1534735420922579.
Sodium bicarbonate, commonly known as baking soda, is widely used in the clinic as an antacid for treating gastric hyperacidity, among other conditions. Chao et al have reported a clinical trial about targeting intratumor lactic acidosis-transarterial chemoembolization. Based on conventional transarterial chemoembolization, the authors added a 5% sodium bicarbonate solution to cytotoxic drugs, resulting in a high local control rate. The explanation for the antitumor effects of sodium bicarbonate is related to acidosis in the tumor microenvironment. In this review, we summarize the findings from studies administering sodium bicarbonate alone or in combination with other anticancer therapies as cancer treatments, and discuss methods for safe and effective use of sodium bicarbonate in the clinic.
碳酸氢钠，俗称小苏打，在临床上被广泛用作抗酸剂，用于治疗胃酸过多等病症。Chao 等人报告了一项关于针对肿瘤内乳酸酸中毒经动脉化疗栓塞的临床试验。基于传统的经动脉化疗栓塞，作者在细胞毒性药物中添加了 5%的碳酸氢钠溶液，从而实现了高局部控制率。碳酸氢钠的抗肿瘤作用的解释与肿瘤微环境中的酸中毒有关。在这篇综述中，我们总结了单独使用或与其他抗癌疗法联合使用碳酸氢钠作为癌症治疗的研究结果，并讨论了在临床上安全有效地使用碳酸氢钠的方法。
