Lee Hoongoo, Koh Dong Hee
Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
Korean J Gastroenterol. 2020 May 25;75(5):240-245. doi: 10.4166/kjg.2020.75.5.240.
Obesity has become a major medical and public health problem worldwide. Recent studies have shown that obesity is a chronic disease that is associated with many diseases, such as gallstone disease, acute pancreatitis, fatty liver, and digestive cancer. Obesity is also a risk factor for the formation of cholesterol gallstones. Clinical and epidemiological studies have suggested that obesity is positively associated with the risk of gallbladder cancer. Obesity may modulate the lipid and endogenous hormones metabolism, affect gallbladder motility, increase the risk of gallstones, and increased the risk of gallbladder cancer. In addition, obesity has been considered a risk factor for pancreatic diseases, including pancreatitis and pancreatic cancer. Obese patients develop systemic and local complications of acute pancreatitis more frequently. Several epidemiologic studies have suggested an association of pancreatic cancer with high body mass and lack of physical activity. This study reviewed the literature on obesity and pancreatobiliary disease in terms of epidemiology and mechanism.
肥胖已成为全球主要的医学和公共卫生问题。最近的研究表明，肥胖是一种与许多疾病相关的慢性疾病，如胆结石病、急性胰腺炎、脂肪肝和消化道癌症。肥胖也是胆固醇胆结石形成的一个危险因素。临床和流行病学研究表明，肥胖与胆囊癌风险呈正相关。肥胖可能会调节脂质和内源性激素代谢，影响胆囊运动，增加胆结石风险，并增加胆囊癌风险。此外，肥胖被认为是包括胰腺炎和胰腺癌在内的胰腺疾病的一个危险因素。肥胖患者更频繁地发生急性胰腺炎的全身和局部并发症。几项流行病学研究表明胰腺癌与高体重和缺乏体育活动有关。本研究从流行病学和机制方面综述了关于肥胖与胰胆疾病的文献。
