University of Hawaii Internal Medicine Residency Program, 1356 Lusitana St, Honolulu, HI, 96813, USA.
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Cardiovasc Interv Ther. 2021 Jul;36(3):363-374. doi: 10.1007/s12928-020-00675-1. Epub 2020 May 24.
This study aimed to compare incidence of IE between BE and SE valves by performing a systematic review and meta-analysis of the literature. We comprehensively searched the databases of MEDLINE and EMBASE from inception to November 2019. Included studies were published observational studies that compared the risk of IE among patients undergoing TAVR employing BE versus SE valves, using the random-effects to calculate risk ratios and 95% confidence intervals (CIs).Ten cohort studies from April 2013 to November 2019 were included in this meta-analysis involving 13,478 subjects (6289 SE and 7189 BE types). Our study showed no statistical difference in IE rates between each type of valves (pooled OR 0.96, 95% CI: 0.68-1.35, p = 0.801 with I2 = 14.7%). There was no difference in IE rate between BE and SE valves following TAVR. Further studies are warranted to confirm our findings.
本研究旨在通过对文献进行系统回顾和荟萃分析，比较生物瓣和机械瓣 TAVR 术后感染性心内膜炎（IE）的发生率。我们全面检索了 MEDLINE 和 EMBASE 数据库，检索时间从建库至 2019 年 11 月。纳入的研究为比较 TAVR 中采用生物瓣和机械瓣时 IE 风险的观察性研究，使用随机效应模型计算风险比和 95%置信区间（CI）。本荟萃分析纳入了 2013 年 4 月至 2019 年 11 月的 10 项队列研究，共涉及 13478 名患者（6289 名机械瓣和 7189 名生物瓣）。我们的研究表明，两种瓣膜类型的 IE 发生率无统计学差异（汇总 OR 0.96，95%CI：0.68-1.35，p = 0.801，I2 = 14.7%）。TAVR 后生物瓣和机械瓣的 IE 发生率无差异。需要进一步的研究来证实我们的发现。
