Dermatology Unit, Department of Medical Applications of Lasers, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Cairo, Egypt.
Pharmaceutical Technology Unit, Department of Medical Applications of Lasers, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Cairo, Egypt.
Arch Dermatol Res. 2021 Apr;313(3):173-180. doi: 10.1007/s00403-020-02093-y. Epub 2020 May 24.
The treatment of acne remains a challenge for dermatologists. A variety of conventional therapies are available for acne treatment such as topical and systemic medications. Although many of these traditional acne treatments are effective, the wide-spread nature of the disease and its sometimes resistant nature delineate the need for alternative therapies. Therefore, over the past decade, phototherapy has been introduced for the treatment of acne, such as pulsed dye lasers (PDLs) and photodynamic therapy (PDT). The aim of this study was to compare the safety and efficacy of PDL and methylene blue-mediated photodynamic therapy (MB-PDT) in the treatment of mild to moderate acne. Split-face clinical trial including fifteen patients presenting with mild to moderate acne were treated with 585 nm PDL on the right side of the face and MB-PDT with 665-nm diode laser on the left side. The photosensitizer MB was prepared in nanoemulgel formulation, and the treatment was carried out for three sessions maximum at 2-weeks intervals. Results revealed that both PDL and MB-PDT were effective therapies in the treatment of acne, as manifested by the reduction of inflammatory and non-inflammatory lesions throughout the treatment period. However, the latter therapy was proven more potent in the reduction of acne severity, and in terms of patients' tolerance. Therefore, it can be concluded that MB in the nanoemulgel form is a promising treatment approach for acne, and can be further experimented in the treatment of other dermatological diseases.
痤疮的治疗仍然是皮肤科医生面临的挑战。有多种常规疗法可用于治疗痤疮，如局部和全身药物治疗。尽管这些传统的痤疮治疗方法中的许多都很有效，但由于该疾病的广泛传播及其有时具有耐药性，因此需要替代疗法。因此，在过去十年中，光疗已被引入痤疮的治疗中，例如脉冲染料激光（PDL）和光动力疗法（PDT）。本研究的目的是比较 PDL 和亚甲蓝介导的光动力疗法（MB-PDT）在治疗轻度至中度痤疮中的安全性和疗效。一项包括 15 名患有轻度至中度痤疮的患者的分割面临床试验，在右侧面部用 585nm PDL 治疗，在左侧用 665nm 二极管激光进行 MB-PDT。光敏剂 MB 被制备成纳米乳凝胶制剂，并且在 2 周的间隔内最多进行 3 次治疗。结果表明，PDL 和 MB-PDT 都是治疗痤疮的有效疗法，表现在整个治疗期间炎症性和非炎症性病变的减少。然而，后者疗法在减少痤疮严重程度方面更有效，而且在患者耐受性方面也是如此。因此，可以得出结论，纳米乳凝胶形式的 MB 是治疗痤疮的有前途的治疗方法，并可以在治疗其他皮肤病方面进一步进行实验。
