Department of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing, 100034, China.
Department of Otorhinolaryngology, Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, 6# Fucheng Road, Haidian District, Beijing, 100048, China.
Eur Arch Otorhinolaryngol. 2020 Oct;277(10):2829-2838. doi: 10.1007/s00405-020-06045-0. Epub 2020 May 25.
Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China.
This multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China. All these patients completed the questionnaire based on RSI. In this study, LPRD was defined as RSI > 13.
There were 9182 with LPRD among the 90,440 eligible participants (10.15%). However, only 1294 had a history of LPRD diagnosis among those with LPRD (14.09%). There were regional differences in the frequency of LPRD (P < 0.001). The proportions of patients with LPRD in males (vs. females), middle- and old-aged patients (vs. young), with current smoking history (vs. no smoking), and current drinking history (vs. no drinking) were significantly higher (all P < 0.001). Middle and old age, current smoking, and drinking history were independent predictors of LPRD (all P < 0.001, OR 1.240, 1.261, and 1.481, respectively). "Sensations of something stuck in throat or a lump in throat", "clearing throat", and "excess throat mucus or postnasal drip" were the most frequent clinical symptoms in patients with LPRD.
LPRD has a high incidence at the OHNS clinics in China. However, the diagnostic status of this disease is not optimistic. Older age, smoking, and drinking history were risk factors for LPRD.
本项全国性研究使用反流症状指数（RSI）调查中国耳鼻喉头颈外科（OHNS）诊所成人咽喉反流病（LPRD）的发病率、诊断现状、危险因素和常见症状。
这项多中心横断面研究于 2017 年 7 月至 10 月在不同机构开展，持续时间为 12 个月。最终从中国 72 家医疗机构共纳入 90440 例符合条件的患者，所有患者均完成了基于 RSI 的问卷调查。本研究中，RSI＞13 定义为 LPRD。
90440 例符合条件的患者中，9182 例（10.15%）患有 LPRD，但其中仅有 1294 例（14.09%）有 LPRD 诊断史。LPRD 频率存在地区差异（P＜0.001）。男性（vs. 女性）、中老年人（vs. 年轻人）、有当前吸烟史（vs. 无吸烟史）和当前饮酒史（vs. 无饮酒史）患者中 LPRD 的比例显著更高（均 P＜0.001）。中老年人、当前吸烟和饮酒史是 LPRD 的独立预测因素（均 P＜0.001，OR 1.240、1.261 和 1.481）。“咽喉部有异物感或哽噎感”“清嗓”和“咽喉部黏液过多或后鼻滴注”是 LPRD 患者最常见的临床症状。
中国 OHNS 诊所 LPRD 发病率较高，但该疾病的诊断状况不容乐观。年龄较大、吸烟和饮酒史是 LPRD 的危险因素。
