Peng Yuting, Xu Dan, Liu Xuelai, He Dan, Wei Lei, Xiong Junwei, Zhou Shitong, Li Minghong, Fang Hongyan
Department of Otolaryngology Head and Neck Surgery，Affiliated Hospital of Southwest Medical University，Luzhou，646000，China.
Department of Otolaryngology Head and Neck Surgery，Chongqing General Hospital.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Apr;35(4):351-354;359. doi: 10.13201/j.issn.2096-7993.2021.04.015.
To investigate the prevalence and affecting factors of laryngopharyngeal reflux disease（LPRD） in otolaryngology head and neck surgery in Chongqing,and to provide a basis for the clinical diagnosis and therapy of LPRD. Multi-center cross-sectional survey method and systematic sampling method were used to select patients at fifteen hospitals in Chongqing from August to November in 2019. Then reflux symptom index（RSI） was investigated. At the same time, the information of the relevant dietary habits, including smoking and drinking, spicy diet, high-fat diet, and satiety was collected. Moreover, the factors related to LRPD（gender, age, symptoms, diet and lifestyle） were analyzed. The composition ratio of LPRD was 11.90%（385/3234） in 3234 effective questionnaires and 385 positive ones. The composition ratio was 12.55%（173/1378） in men and 11.42%（212/1856） in women. The difference between the two groups was statistically significant（<0.05）. The difference in composition ratio among different age groups was statistically significant（<0.05）, with the highest composition ratio between 40 and 59 years old（170/1390）. Constant throat-clearing（symptom 2） and globus sensation（symptom 8） were most correlated with LPRD. Logistic regression analysis showed that spicy diet, over eating, and smoking were highly related to LPRD. Globus sensation and constant throat-clearing are the most common symptoms in LPRD patients. Spicy diet, over eating, and smoking are risk factors for LPRD.
探讨重庆地区耳鼻咽喉头颈外科喉咽反流病（LPRD）的患病率及影响因素，为LPRD的临床诊断与治疗提供依据。采用多中心横断面调查法及系统抽样法，于2019年8月至11月选取重庆市15家医院的患者，进行反流症状指数（RSI）调查。同时，收集相关饮食习惯信息，包括吸烟、饮酒、辛辣饮食、高脂饮食及饱腹感情况。此外，分析与LRPD相关的因素（性别、年龄、症状、饮食及生活方式）。3234份有效问卷中，LPRD的构成比为11.90%（385/3234），阳性问卷385份。男性构成比为12.55%（173/1378），女性为11.42%（212/1856）。两组差异有统计学意义（<0.05）。不同年龄组构成比差异有统计学意义（<0.05），40～59岁组构成比最高（170/1390）。频繁清嗓（症状2）和咽异感症（症状8）与LPRD相关性最强。Logistic回归分析显示，辛辣饮食、暴饮暴食及吸烟与LPRD高度相关。咽异感症和频繁清嗓是LPRD患者最常见的症状。辛辣饮食、暴饮暴食及吸烟是LPRD的危险因素。
