Konrádová V, Janota J, Sulová J, Suková B, Copová M
Research Institute for Child Development, University Hospital, Prague, Czechoslovakia.
Respiration. 1988;54(1):24-32. doi: 10.1159/000195498.
Numerous signs of pathological alteration were induced in the pseudostratified ciliated epithelium by a 2-hour exposure to 90% oxygen. The ciliary border injury was especially conspicuous, the mean number of cilia in a given area was significantly (p less than 0.005) reduced and morphological signs of impaired self-cleaning ability were revealed. Ciliated cells were severely injured showing apical blebbing and swelling of cell organelles. The reaction of goblet cells to exposure to O2 was rapid discharge of mucus, but the mechanism of mucus evacuation was not substantially influenced. At the ultrastructural level, only a mild effect of humidification of the oxygen was observed.
通过暴露于90%氧气2小时，假复层纤毛上皮出现了许多病理改变迹象。纤毛边界损伤尤为明显，给定区域内纤毛的平均数量显著减少（p<0.005），并显示出自我清洁能力受损的形态学迹象。纤毛细胞受到严重损伤，表现为顶端起泡和细胞器肿胀。杯状细胞对氧气暴露的反应是迅速排出黏液，但黏液排出机制并未受到实质性影响。在超微结构水平上，仅观察到氧气加湿的轻微作用。
