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Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous?

作者信息

Funck-Brentano Christian, Salem Joe-Elie

机构信息

AP-HP, Sorbonne Université, Pitié-Salpêtrière Hospital, Department of Pharmacology and Clinical Investigation Centre, Paris 75013, France; INSERM, CIC-1901 and UMR-S 1166, Sorbonne Université, Faculty of Medicine, Paris, France.

出版信息

Lancet. 2020 May 22. doi: 10.1016/S0140-6736(20)31174-0.

DOI:10.1016/S0140-6736(20)31174-0

PMID:32450109

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7255131/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd12/7255131/eb0f784d8382/fx1_lrg.jpg

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本文引用的文献

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Assessment of Multi-Ion Channel Block in a Phase I Randomized Study Design: Results of the CiPA Phase I ECG Biomarker Validation Study.

Clin Pharmacol Ther. 2019 Apr;105(4):943-953. doi: 10.1002/cpt.1303. Epub 2019 Jan 18.

Additive Proarrhythmic Effect of Combined Treatment with QT-Prolonging Agents.

Cardiovasc Toxicol. 2018 Feb;18(1):84-90. doi: 10.1007/s12012-017-9416-0.

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Circ Arrhythm Electrophysiol. 2017 Apr;10(4). doi: 10.1161/CIRCEP.115.003560.

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J Antimicrob Chemother. 2017 May 1;72(5):1272-1274. doi: 10.1093/jac/dkw591.

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Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous?

作者信息

Funck-Brentano Christian, Salem Joe-Elie

机构信息

出版信息

Lancet. 2020 May 22. doi: 10.1016/S0140-6736(20)31174-0.

DOI:10.1016/S0140-6736(20)31174-0

PMID:32450109

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7255131/

Abstract

摘要

相似文献

Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous?

Lancet. 2020 May 22. doi: 10.1016/S0140-6736(20)31174-0.

Use of hydroxychloroquine and chloroquine in patients with COVID-19: a meta-analysis of randomized clinical trials.

Pathog Glob Health. 2021 May;115(3):139-150. doi: 10.1080/20477724.2021.1884807. Epub 2021 Feb 11.

Why Your Patients' Believing Hydroxychloroquine and Chloroquine Are 90% Effective for COVID-19 Is 100% Dangerous.

J Clin Pharmacol. 2020 Aug;60(8):949-953. doi: 10.1002/jcph.1687. Epub 2020 Jul 1.

Hydroxychloroquine/ chloroquine as a treatment choice or prophylaxis for Covid-19 at the primary care level in developing countries: A Primum non Nocere dilemma.

J Neurol Sci. 2020 Aug 15;415:116972. doi: 10.1016/j.jns.2020.116972. Epub 2020 Jun 3.

Toxicity of chloroquine and hydroxychloroquine following therapeutic use or overdose.

Clin Toxicol (Phila). 2021 Jan;59(1):12-23. doi: 10.1080/15563650.2020.1817479. Epub 2020 Sep 22.

Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19.

Cochrane Database Syst Rev. 2021 Feb 12;2(2):CD013587. doi: 10.1002/14651858.CD013587.pub2.

Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Systematic Review.

Ann Intern Med. 2020 Aug 18;173(4):287-296. doi: 10.7326/M20-2496. Epub 2020 May 27.

Real-Life Data on Hydroxychloroquine or Chloroquine with or Without Azithromycin in COVID-19 Patients: A Retrospective Analysis in Brazil.

Arq Bras Cardiol. 2023 Sep;120(9):e20220935. doi: 10.36660/abc.20220935.

RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis.

Lancet. 2020 May 22. doi: 10.1016/S0140-6736(20)31180-6.

Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review.

Front Public Health. 2020 May 29;8:252. doi: 10.3389/fpubh.2020.00252. eCollection 2020.

引用本文的文献

Targeting natural products against SARS-CoV-2.

Environ Sci Pollut Res Int. 2022 Jun;29(28):42404-42432. doi: 10.1007/s11356-022-19770-2. Epub 2022 Apr 1.

Protocol of investigation into reporting quality of RCT abstracts on COVID-19 pursuant to CONSORT (CoCo study)-a review.

Trials. 2021 Dec 24;22(1):952. doi: 10.1186/s13063-021-05937-8.

The protective role of vitamin C in the management of COVID-19: A Review.

J Egypt Public Health Assoc. 2021 Dec 11;96(1):33. doi: 10.1186/s42506-021-00095-w.

Hydroxychloroquine and Chloroquine in Prophylaxis and Treatment of COVID-19: What Is Known?

J Pharm Bioallied Sci. 2021 Jan-Mar;13(1):4-10. doi: 10.4103/jpbs.JPBS_404_20. Epub 2020 Oct 6.

Clinical Research Redirection and Optimization During a Pandemic.

Anesthesiol Clin. 2021 Jun;39(2):379-388. doi: 10.1016/j.anclin.2021.03.004.

Impact of Treatment Regimens on Antibody Response to the SARS-CoV-2 Coronavirus.

Front Immunol. 2021 Apr 15;12:580147. doi: 10.3389/fimmu.2021.580147. eCollection 2021.

Progress in the risk assessment of hydroxychloroquine in frail elderly people.

Aging Med (Milton). 2020 Dec 25;4(1):53-57. doi: 10.1002/agm2.12140. eCollection 2021 Mar.

Approaches for the Treatment of SARS-CoV-2 Infection: A Pharmacologic View and Literature Review.

Iran J Pharm Res. 2020 Summer;19(3):258-281. doi: 10.22037/ijpr.2020.113821.14506.

COVID-19 and the generation of novel scientific knowledge: Research questions and study designs.

J Eval Clin Pract. 2021 Jun;27(3):694-707. doi: 10.1111/jep.13550. Epub 2021 Feb 15.

From quarantine room: Physician perspective.

J Family Med Prim Care. 2020 Oct 30;9(10):5092-5102. doi: 10.4103/jfmpc.jfmpc_896_20. eCollection 2020 Oct.

本文引用的文献

RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis.

Lancet. 2020 May 22. doi: 10.1016/S0140-6736(20)31180-6.

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19).

JAMA Cardiol. 2020 Jul 1;5(7):811-818. doi: 10.1001/jamacardio.2020.1017.

Assessment of Multi-Ion Channel Block in a Phase I Randomized Study Design: Results of the CiPA Phase I ECG Biomarker Validation Study.

Clin Pharmacol Ther. 2019 Apr;105(4):943-953. doi: 10.1002/cpt.1303. Epub 2019 Jan 18.

Additive Proarrhythmic Effect of Combined Treatment with QT-Prolonging Agents.

Cardiovasc Toxicol. 2018 Feb;18(1):84-90. doi: 10.1007/s12012-017-9416-0.

Azithromycin Causes a Novel Proarrhythmic Syndrome.

Circ Arrhythm Electrophysiol. 2017 Apr;10(4). doi: 10.1161/CIRCEP.115.003560.

Antimicrobials and QT prolongation.

J Antimicrob Chemother. 2017 May 1;72(5):1272-1274. doi: 10.1093/jac/dkw591.

Early treatment with intravenous lipid emulsion in a potentially lethal hydroxychloroquine intoxication.

Neth J Med. 2016 Jun;74(5):210-4.

An update on risk factors for drug-induced arrhythmias.

Expert Rev Clin Pharmacol. 2016;9(1):117-27. doi: 10.1586/17512433.2016.1100073. Epub 2015 Oct 13.

Epidemiology of symptomatic drug-induced long QT syndrome and Torsade de Pointes in Germany.

Europace. 2014 Jan;16(1):101-8. doi: 10.1093/europace/eut214. Epub 2013 Jul 5.

Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol.

Br J Clin Pharmacol. 2014 Mar;77(3):522-31. doi: 10.1111/bcp.12201.

Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous?

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Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous?

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