Uddin Mohammad Sarowar, Millat Md Shalahuddin, Baral Prodip Kumar, Ferdous Mahmuda, Uddin Md Giash, Sarwar Md Shahid, Islam Mohammad Safiqul
Department of Pharmacy, Noakhali Science & Technology University, Noakhali, 3814, Bangladesh.
Department of Pharmacy, University of Chittagong, Chittagong, 4331, Bangladesh.
J Egypt Public Health Assoc. 2021 Dec 11;96(1):33. doi: 10.1186/s42506-021-00095-w.
The outbreak of coronavirus infectious disease-2019 (COVID-19) is globally deemed a significant threat to human life. Researchers are searching for prevention strategies, mitigation interventions, and potential therapeutics that may reduce the infection's severity. One such means that is highly being talked in online and in social media is vitamin C.
Vitamin C is a robust antioxidant that boosts the immune system of the human body. It helps in normal neutrophil function, scavenging of oxidative species, regeneration of vitamin E, modulation of signaling pathways, activation of pro-inflammatory transcription factors, activation of the signaling cascade, regulation of inflammatory mediators, and phagocytosis and increases neutrophil motility to the site of infection. All of these immunological functions are required for the prevention of COVID-19 infection.
Considering the role of vitamin C, it would be imperative to administrate vitamin C for the management of severe COVID-19. However, there is no specific clinical data available to confirm the use of vitamin C in the current pandemic.
2019年冠状病毒病(COVID-19)的爆发在全球范围内被视为对人类生命的重大威胁。研究人员正在寻找可能降低感染严重程度的预防策略、缓解干预措施和潜在治疗方法。维生素C就是在网络和社交媒体上被广泛讨论的一种方法。
维生素C是一种强大的抗氧化剂,可增强人体免疫系统。它有助于正常的中性粒细胞功能、清除氧化物质、维生素E的再生、信号通路的调节、促炎转录因子的激活、信号级联的激活、炎症介质的调节以及吞噬作用,并增加中性粒细胞向感染部位的移动性。所有这些免疫功能都是预防COVID-19感染所必需的。
考虑到维生素C的作用,对于重症COVID-19的治疗,给予维生素C势在必行。然而,目前尚无具体临床数据证实维生素C在当前疫情中的应用。