Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, Canada; Experimental Pathology Unit, Department of Pathology, McGill University, Montréal, Canada.
Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, Quebec City, Canada; CUO-Recherche and Axe médecine régénératrice, Centre de recherche du CHU de Québec-Université Laval, Quebec City, Canada; Centre de recherche sur le cancer de l'Université Laval, Quebec City, Canada; Centre de recherche en organogénèse expérimentale de l'Université Laval/LOEX, Quebec City, Canada.
Semin Cancer Biol. 2021 Jun;71:65-85. doi: 10.1016/j.semcancer.2020.05.003. Epub 2020 May 22.
Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the liver. Despite the identification of the early driver mutations during the development of the pathology, the process of UM metastasis is still not fully comprehended. A better understanding of the genetic, molecular, and environmental factors participating to its spread and metastatic outgrowth could provide additional approaches for UM treatment. In this review, we will discuss the advances made towards the understanding of the pathogenesis of metastatic UM, summarize the current and prospective treatments, and introduce some of the ongoing research in this field.
葡萄膜黑色素瘤（UM）是一种眼内肿瘤，具有向肝脏扩散的倾向。尽管在病理学发展过程中已经确定了早期的驱动突变，但 UM 转移的过程仍未完全理解。更好地了解参与其扩散和转移生长的遗传、分子和环境因素，可为 UM 的治疗提供更多的方法。在这篇综述中，我们将讨论在理解转移性 UM 的发病机制方面取得的进展，总结目前和未来的治疗方法，并介绍该领域正在进行的一些研究。
