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序贯双侧全膝关节置换术是否应限于80岁以下患者?一项双臂倾向匹配研究。

Should Sequential Bilateral Total Knee Arthroplasty Be Limited to Patients Younger than 80? A Two-Arm Propensity Matched Study.

作者信息

Klasan Antonio, Putnis Sven Edward, Yeo Wai Weng, Myat Darli, Fritsch Brett Andrew, Coolican Myles Raphael, Parker David Anthony

机构信息

Sydney Orthopaedic Research Institute, Chatswood, New South Wales, Australia.

Department of Medicine, University of New South Wales, Sydney, Australia.

出版信息

J Knee Surg. 2021 Dec;34(14):1579-1586. doi: 10.1055/s-0040-1712100. Epub 2020 May 25.

Abstract

Despite multiple studies, there remains a debate on the safety of bilateral total knee arthroplasty (BTKA) in the average age patient, with a paucity of data on the outcome of BTKA in an elderly population. This study included 89 patients aged 80 years and older undergoing sequential BTKA over 14 years were identified in a prospectively collected database. Two matched comparison groups were created: patients under 80 undergoing sequential BTKA and patients over 80 undergoing unilateral TKA (UTKA). An analysis of complications, mortality, revision, and patient-reported outcome measures was performed. Mean age of the elderly cohorts was similar: 82.6 for BTKA and 82.9 for UTKA. The average age BTKA cohort had a mean age of 69.1. Complication rates were higher in bilateral cohorts, more so in the elderly BTKA cohort. Pulmonary embolism (PE) was observed in bilateral cohorts only. In these patients, history of PE and ischemic heart disease was a strong predictive factor for developing a major complication. There was no difference in revision rates and infection rates between the three cohorts, and no difference in patient survivorship between the two elderly cohorts. Through the combination of low revision and high survivorship rates and comparable clinical outcomes, this article demonstrates that simultaneous BTKA is an appropriate option to consider for an elderly patient, with proper patient selection and perioperative management. The demonstrated risk groups show that emphasis on patient selection should be focused on medical history rather than chronological age.

摘要

尽管进行了多项研究,但对于普通年龄患者双侧全膝关节置换术(BTKA)的安全性仍存在争议,而关于老年人群BTKA结局的数据却很匮乏。本研究在一个前瞻性收集的数据库中,确定了89例年龄在80岁及以上、在14年期间接受序贯BTKA的患者。创建了两个匹配的对照组:年龄在80岁以下接受序贯BTKA的患者和年龄在80岁以上接受单侧全膝关节置换术(UTKA)的患者。对并发症、死亡率、翻修率和患者报告的结局指标进行了分析。老年队列的平均年龄相似:BTKA组为82.6岁,UTKA组为82.9岁。BTKA队列的平均年龄为69.1岁。双侧队列的并发症发生率更高,老年BTKA队列更是如此。仅在双侧队列中观察到肺栓塞(PE)。在这些患者中,PE病史和缺血性心脏病是发生主要并发症的强烈预测因素。三个队列之间的翻修率和感染率没有差异,两个老年队列之间的患者生存率也没有差异。通过低翻修率和高生存率以及可比的临床结局相结合,本文表明,对于老年患者,在进行适当的患者选择和围手术期管理的情况下,同期BTKA是一个值得考虑的合适选择。所显示的风险组表明,对患者选择的重点应放在病史而非实际年龄上。

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