Skinnider L F, Ghadially F N
Br J Cancer. 1977 May;35(5):657-67. doi: 10.1038/bjc.1977.101.
In an ultrastructural study by transmission and scanning electron microscopy of two cases of malignant histiocytosis and a case of leukaemic reticulum-cell sarcoma, unusual blisters, blebs and worm-like processes were detected on the cell surfaces. The blisters (containing clear fluid) appear to develop by a single-membrane-bound vacuole approaching the cell membrane, and acquiring another membrane on discharging from the cell. The blebs (containing cytoplasm) appear to correspond to the already described phenomenon of zeiosis. The term "vermipodia" is given to the worm-like processes. The underlying factors responsible for these phenomena is not clear, but the exocytosis of the clear blisters resembled that of leukaemic blasts exposed to the action of vinca alkaloids. As two of the cases were being treated with vincristine, it may be that a drug action is implicated. However, it is also possible that these changes may be the morphological expression of some of the changes in the cell surface membrane that occur in malignant transformation.
在一项通过透射电子显微镜和扫描电子显微镜对两例恶性组织细胞增多症和一例白血病性网状细胞肉瘤进行的超微结构研究中，在细胞表面检测到了异常的水泡、泡状膨出和蠕虫样突起。水泡（含有清亮液体）似乎是由一个单膜结合的液泡靠近细胞膜形成的，并且在从细胞排出时获得另一层膜。泡状膨出（含有细胞质）似乎与已描述的出胞现象相对应。将“蠕虫样足”这一术语用于蠕虫样突起。导致这些现象的潜在因素尚不清楚，但清亮水泡的胞吐作用类似于暴露于长春花生物碱作用下的白血病原始细胞的胞吐作用。由于其中两例正在接受长春新碱治疗，可能与药物作用有关。然而，这些变化也有可能是恶性转化过程中细胞表面膜发生的一些变化的形态学表现。
