Lombardi L, Carbone A, Pilotti S, Rilke F
Histopathology. 1978 Sep;2(5):315-28. doi: 10.1111/j.1365-2559.1978.tb01724.x.
A morphological, histological, and ultrastructural investigation was carried out on a series of six cases of malignant histiocytosis observed between 1973 and 1977. All lymph nodes were obtained prior to treatment. The histological findings revealed that the proliferating cell type was in all cases represented by histiocytes of varying degrees of atypia and with consistent phagocytic activity. In four cases, the histiocytic cellular proliferation also showed some degree of cohesiveness and, in two cases, there was capsular invasion. In three cases blood vessel invasion by malignant cells could be seen within the lymph node and in the surrounding tissue. On electron microscopy the tumour cells of malignant histiocytosis appeared to be pleomorphic with three types of cells: undifferentiated cells, histiocytes with variable degrees of differentiation, and cells with intermediate features. In particular, nonphagocytic and actively phagocytic histiocytes could be identified. The histological and ultrastructural data further support the idea that malignant histiocytosis is a disease that is related to the neoplastic proliferation of moderately differentiated histiocytes and their precursors. The latter may undergo various transformations with either apparently benign or definitely atypical morphological features.
对1973年至1977年间观察到的6例恶性组织细胞增多症病例进行了形态学、组织学和超微结构研究。所有淋巴结均在治疗前获取。组织学检查结果显示，所有病例中增殖细胞类型均为不同程度异型性且具有一致吞噬活性的组织细胞。4例中，组织细胞性细胞增殖还表现出一定程度的聚集性，2例存在包膜侵犯。3例在淋巴结内及周围组织可见恶性细胞侵犯血管。电镜下，恶性组织细胞增多症的肿瘤细胞表现为多形性，有三种类型的细胞：未分化细胞、不同程度分化的组织细胞以及具有中间特征的细胞。特别是，可以识别出非吞噬性和活跃吞噬性组织细胞。组织学和超微结构数据进一步支持了恶性组织细胞增多症是一种与中度分化组织细胞及其前体的肿瘤性增殖相关的疾病这一观点。后者可能经历各种转变，具有明显良性或明确异型的形态特征。
