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牛呼吸道疾病的病毒病疫苗接种:活疫苗与灭活抗原疫苗、鼻腔内接种与肠胃外接种,有何证据?

Bovine Respiratory Disease Vaccination Against Viral Pathogens: Modified-Live Versus Inactivated Antigen Vaccines, Intranasal Versus Parenteral, What Is the Evidence?

机构信息

Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Large Animal Teaching Hospital, 2020 J.T. Vaughn, Auburn, AL 36849, USA.

Department of Population Medicine, College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks Drive, Athens, GA 30602, USA.

出版信息

Vet Clin North Am Food Anim Pract. 2020 Jul;36(2):461-472. doi: 10.1016/j.cvfa.2020.03.006.

DOI:10.1016/j.cvfa.2020.03.006
PMID:32451035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7244452/
Abstract

Vaccination of cattle against viral respiratory pathogens to minimize losses associated with bovine respiratory disease (BRD) is a common practice among producers and veterinarians. Three different calf populations in which BRD is most prevalent (recently weaned beef calves, preweaning beef calves, and young dairy calves) are the principal focus of morbidity and mortality prevention through vaccination; however, the evidence of vaccination efficacy is inconsistent in the literature. This review addresses the evidence of efficacy of vaccination in the prevention or reduction of naturally occurring and experimentally induced BRD in each calf group.

摘要

给牛接种病毒呼吸道病原体疫苗以尽量减少与牛呼吸道疾病 (BRD) 相关的损失是生产者和兽医的常见做法。最近断奶的肉牛犊、未断奶的肉牛犊和年轻的奶牛犊这三个 BRD 最常见的小牛群体是通过疫苗接种预防发病率和死亡率的主要关注点;然而,文献中疫苗效力的证据并不一致。本综述讨论了疫苗在预防或减少每个小牛群体中自然发生和实验诱导的 BRD 的功效证据。

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本文引用的文献

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Protection against bovine respiratory syncytial virus in calves vaccinated with adjuvanted modified live vaccine administered in the face of maternal antibody.在存在母源抗体的情况下,用佐剂改良的活疫苗对犊牛进行免疫接种,以预防牛呼吸道合胞体病毒。
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Vaccine. 2019 Dec 3;37(51):7455-7462. doi: 10.1016/j.vaccine.2019.09.080. Epub 2019 Oct 4.
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J Dairy Sci. 2019 Aug;102(8):7320-7328. doi: 10.3168/jds.2018-15463. Epub 2019 Jun 13.
4
A randomized controlled trial to test the effect of on-arrival vaccination and deworming on stocker cattle health and growth performance.一项随机对照试验,旨在测试到场时接种疫苗和驱虫对架子牛健康及生长性能的影响。
Bov Pract (Stillwater). 2018 Spring;52(1):26-33.
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Comparative efficacy of modified-live and inactivated vaccines in boosting responses to bovine respiratory syncytial virus following neonatal mucosal priming of beef calves.在新生肉用犊牛进行黏膜初次免疫后,改良活疫苗和灭活疫苗在增强对牛呼吸道合胞体病毒反应方面的比较效果。
Can Vet J. 2018 Dec;59(12):1311-1319.
6
Effects of vaccination timing against respiratory pathogens on performance, antibody response, and health in feedlot cattle.疫苗接种时机对育肥牛呼吸道病原体的影响及其对生产性能、抗体应答和健康的影响。
J Anim Sci. 2019 Feb 1;97(2):620-630. doi: 10.1093/jas/sky466.
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Best management practices for newly weaned calves for improved health and well-being.改善健康和福利的新断奶犊牛最佳管理实践。
J Anim Sci. 2017 May;95(5):2170-2182. doi: 10.2527/jas.2016.1006.
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Efficacy of intranasal vaccination with a multivalent vaccine containing temperature-sensitive modified-live bovine herpesvirus type 1 for protection of seronegative and seropositive calves against respiratory disease.使用含有温度敏感型减毒活牛疱疹病毒1型的多价疫苗进行鼻内接种,对血清阴性和血清阳性犊牛预防呼吸道疾病的效果。
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