Unit of Radiology, Department of Diagnostic Imaging, E.O. Galliera Hospital, Genoa, Italy.
DISSAL - Department of Health Sciences, University of Genoa, Via Antonio Pastore, 1, 16132, Genoa, GE, Italy.
Abdom Radiol (NY). 2020 Nov;45(11):3896-3906. doi: 10.1007/s00261-020-02591-7.
To assess the diagnostic value of retrospectively fused PET/MRI by comparing the detection rates (DRs) of fused CuCl PET/MRI vs. fused F-Choline PET/MRI in patients with suspected prostatic cancer (PCa) recurrence. The secondary objective was to compare the DRs of fused PET/MRI vs. those of the separate imaging modalities.
We retrospectively evaluated 50 PCa patients with biochemical relapse after radical prostatectomy (RP) or radiotherapy (RT). All patients underwent CuCl PET/CT, F-Choline PET/CT, and multiparametric magnetic resonance imaging (mpMRI) within 15 days. Fused CuCl-PET/MRI and fused F-Choline PET/MRI images were obtained by retrospective co-registration of MRI and PET images. Experienced readers interpreted the images, and the DRs of each imaging modality were assessed.
In the patient-based analysis, overall DRs of fused CuCl PET/MRI, fused F-Choline PET/MRI, CuCl PET/CT, F-Choline PET/CT, and mpMRI were 88%, 68%, 82%, 56%, and 74%, respectively. In the lesion-based analysis, overall DRs of fused CuCl PET/MRI, fused F-Choline PET/MRI, CuCl PET/CT, F-Choline PET/CT, and mpMRI were 95%, 66%, 87%, 58%, and 71%, respectively.
Retrospectively fused PET/MRI is able to overcome the limitations of the separate interpretation of the individual imaging modalities. Fused CuCl PET/MRI provided the highest diagnostic performance in the detection of PCa local relapse.
通过比较疑似前列腺癌（PCa）复发患者融合 CuCl PET/MRI 与融合 F-Choline PET/MRI 的检出率（DR），评估回顾性融合 PET/MRI 的诊断价值。次要目标是比较融合 PET/MRI 与单独成像方式的 DR。
我们回顾性评估了 50 例根治性前列腺切除术（RP）或放疗（RT）后生化复发的 PCa 患者。所有患者均在 15 天内接受了 CuCl PET/CT、F-Choline PET/CT 和多参数磁共振成像（mpMRI）检查。通过 MRI 和 PET 图像的回顾性配准获得融合的 CuCl-PET/MRI 和融合的 F-Choline PET/MRI 图像。有经验的读者对图像进行解读，并评估每种成像方式的 DR。
在基于患者的分析中，融合 CuCl PET/MRI、融合 F-Choline PET/MRI、CuCl PET/CT、F-Choline PET/CT 和 mpMRI 的整体 DR 分别为 88%、68%、82%、56%和 74%。在基于病灶的分析中，融合的 CuCl PET/MRI、融合的 F-Choline PET/MRI、CuCl PET/CT、F-Choline PET/CT 和 mpMRI 的整体 DR 分别为 95%、66%、87%、58%和 71%。
回顾性融合 PET/MRI 能够克服单独解读各成像方式的局限性。融合的 CuCl PET/MRI 在检测 PCa 局部复发方面提供了最高的诊断性能。
