口腔癌患者基于零回波时间的 PET/MRI 衰减校正：初步经验。

Zero Echo Time-Based PET/MRI Attenuation Correction in Patients With Oral Cavity Cancer: Initial Experience.

机构信息

From the Biomedical Imaging Research Center.

Department of Otolaryngology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

出版信息

Clin Nucl Med. 2020 Jul;45(7):501-505. doi: 10.1097/RLU.0000000000003091.

DOI:10.1097/RLU.0000000000003091

PMID:32453083

Abstract

PURPOSE

The aims of this study were to demonstrate the feasibility of zero echo time (ZTE) MRI for jawbone identification, and to evaluate the quantitative performance of F-FDG PET/MRI with ZTE-based attenuation correction (ZTE-AC) compared with PET/CT and PET/MRI with Dixon MR-based AC (Dixon-AC) in patients with oral cavity cancer (OCC).

MATERIALS AND METHODS

Thirteen OCC patients underwent whole-body F-FDG PET/CT and subsequent regional PET/MRI with Dixon-AC and ZTE-AC in 1 day. SUVs of the primary OCC and metastatic cervical lymph nodes (CLNs) were measured on PET/CT (SUVCT), PET/MRI with Dixon-AC (SUVDixon), and ZTE-AC (SUVZTE). The SUVs were then compared.

RESULTS

The ZTE MRI scans minimized the effects of metal artifacts from dentures, and ZTE-AC maps correctly delineated the jawbones. SUVDixon and SUVZTE had significant positive correlations with SUVCT (Pearson r = 0.97 and r = 0.99 for OCC, and r = 0.98 and r = 0.98 for CLNs, respectively). The mean ± SD of SUVCT, SUVDixon, and SUVZTE were 14.4 ± 8.0, 14.5 ± 8.6, and 15.6 ± 8.8 for OCC, and 6.3 ± 3.0, 8.0 ± 4.0, and 7.6 ± 3.9 for CLNs, respectively. For OCCs, SUVZTE was significantly higher than SUVCT (P < 0.05), whereas there was no significant difference between SUVCT and SUVDixon or between SUVDixon and SUVZTE. For CLNs, SUVDixon and SUVZTE were significantly higher than SUVCT (P < 0.01 and P < 0.05, respectively), and SUVDixon was significantly higher than SUVZTE (P < 0.01).

CONCLUSIONS

ZTE MRI can correctly identify jawbones while minimizing the effects of metal artifacts. The ZTE-AC method in F-FDG PET/MRI reduces the underestimation of tracer uptake due to Dixon-AC jawbone errors and improves the quantitative performance of PET for OCC patients.

摘要

目的

本研究旨在展示零回波时间（ZTE）MRI 用于颌骨识别的可行性，并评估基于 F-FDG PET/MRI 的 ZTE 衰减校正（ZTE-AC）与 PET/CT 和基于 Dixon MR 的 AC（Dixon-AC）相比在口腔癌（OCC）患者中的定量性能。

材料和方法

13 例 OCC 患者在 1 天内接受全身 F-FDG PET/CT 和随后的局部 PET/MRI 检查，包括 Dixon-AC 和 ZTE-AC。在 PET/CT（SUVCT）、基于 Dixon-AC 的 PET/MRI（SUVDixon）和 ZTE-AC（SUVZTE）上测量原发 OCC 和转移性颈部淋巴结（CLNs）的 SUV。然后比较 SUV。

结果

ZTE MRI 扫描最大限度地减少了义齿金属伪影的影响，ZTE-AC 图正确地描绘了颌骨。SUVDixon 和 SUVZTE 与 SUVCT 呈显著正相关（OCC 的 Pearson r = 0.97 和 r = 0.99，CLNs 的 r = 0.98 和 r = 0.98）。OCC 的 SUVCT、SUVDixon 和 SUVZTE 的平均值±标准差分别为 14.4±8.0、14.5±8.6 和 15.6±8.8，CLNs 的 SUVCT、SUVDixon 和 SUVZTE 的平均值±标准差分别为 6.3±3.0、8.0±4.0 和 7.6±3.9。对于 OCC，SUVZTE 明显高于 SUVCT（P < 0.05），而 SUVCT 与 SUVDixon 或 SUVDixon 与 SUVZTE 之间无显著差异。对于 CLNs，SUVDixon 和 SUVZTE 明显高于 SUVCT（P < 0.01 和 P < 0.05），SUVDixon 明显高于 SUVZTE（P < 0.01）。