Rooze M I, Kaasik A E
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(12):18-21.
Dynamic measurements in the cerebrospinal fluid (CSF) of the activities of lactate dehydrogenase (LDH), its first isoenzyme (LDH1), aspartate amino transferase (AsAT), alanine amino transferase (AlAT), creatine phosphokinase (CPK), gamma-glutamyl transpeptidase (GGT) and alkaline phosphatases (ALP) were performed in 99 patients with ischemic stroke. The mean activities of LDH, LDH1, AsAT, CPC and GGT in the CSF of the patients significantly exceeded those in the control group during the first and second weeks of the disease. The increased activities of LDH, LDH1, CPK and AsAT in patients with ischemic stroke indicate the severity of cerebral lesion and resultant hypoxia of the cerebral tissue. High levels of enzymic activity, particularly over a long period of time, always predict a poor outcome.
对99例缺血性中风患者的脑脊液（CSF）中的乳酸脱氢酶（LDH）、其第一种同工酶（LDH1）、天冬氨酸氨基转移酶（AsAT）、丙氨酸氨基转移酶（AlAT）、肌酸磷酸激酶（CPK）、γ-谷氨酰转肽酶（GGT）和碱性磷酸酶（ALP）的活性进行了动态测量。在疾病的第一周和第二周，患者脑脊液中LDH、LDH1、AsAT、CPK和GGT的平均活性显著超过对照组。缺血性中风患者中LDH、LDH1、CPK和AsAT活性的增加表明脑损伤的严重程度以及由此导致的脑组织缺氧。酶活性水平高，尤其是在很长一段时间内，总是预示着预后不良。
