[Enzymatic activity of the cerebrospinal fluid in patients with cerebral infarct].

Dynamic measurements in the cerebrospinal fluid (CSF) of the activities of lactate dehydrogenase (LDH), its first isoenzyme (LDH1), aspartate amino transferase (AsAT), alanine amino transferase (AlAT), creatine phosphokinase (CPK), gamma-glutamyl transpeptidase (GGT) and alkaline phosphatases (ALP) were performed in 99 patients with ischemic stroke. The mean activities of LDH, LDH1, AsAT, CPC and GGT in the CSF of the patients significantly exceeded those in the control group during the first and second weeks of the disease. The increased activities of LDH, LDH1, CPK and AsAT in patients with ischemic stroke indicate the severity of cerebral lesion and resultant hypoxia of the cerebral tissue. High levels of enzymic activity, particularly over a long period of time, always predict a poor outcome.