Department of Dermatology, Oregon Health & Science University, Portland, Oregon.
School of Medicine, Oregon Health & Science University, Portland, Oregon.
J Am Acad Dermatol. 2021 Feb;84(2):283-289. doi: 10.1016/j.jaad.2020.05.095. Epub 2020 May 23.
Current valid instruments that measure the signs of atopic dermatitis in clinical trials may not be suitable for clinical practice because of their complexity. The product of a clinician-derived 5-point signs global assessment and body surface area (SGA × BSA) may represent a simple approach to quickly assess the severity of signs in patients with atopic dermatitis in clinical practice.
Evaluate the basic measurement properties of the SGA × BSA.
Retrospective chart review of patients with atopic dermatitis treated in an outpatient dermatology clinic at Oregon Health & Science University from 2015 to 2018 who had a recorded BSA and SGA.
We identified 138 patients completing 325 clinic visits. SGA × BSA demonstrated strong and statistically significant (P < .001) correlations with the Eczema Area and Severity Index (r = 0.91, n = 19), average daily pruritus (r = 0.71, n = 177), patient global assessment (r = 0.74, n = 170), and a derived global scale composed of the average of 4 signs rated between 0 and 3 (r = 0.77, n = 282). Acceptability, responsiveness, and floor or ceiling effects of the measure were deemed adequate. Severity banding was maximized at 1, 21, and 87 (κ = 0.4902).
The patient cohort was gathered exclusively from a tertiary care clinic setting in the Pacific Northwest and lacked ethnic diversity.
The results from this study suggest that SGA × BSA is a valid and feasible instrument for atopic dermatitis signs in clinical practice.
目前用于临床试验的评估特应性皮炎体征的有效工具可能因过于复杂而不适用于临床实践。基于临床医生的 5 分制体征整体评估与体表面积（SGA×BSA）的乘积可能是一种简单方法，可快速评估临床实践中特应性皮炎患者的体征严重程度。
评估 SGA×BSA 的基本测量特性。
对俄勒冈健康与科学大学皮肤科门诊于 2015 年至 2018 年期间就诊、有记录的体表面积和 SGA 的特应性皮炎患者进行回顾性图表审查。
我们共确定了 138 例完成了 325 次就诊的患者。SGA×BSA 与湿疹面积和严重程度指数（EASI）（r=0.91，n=19）、平均每日瘙痒（r=0.71，n=177）、患者整体评估（r=0.74，n=170）和由 4 项评分在 0 到 3 之间的体征组成的平均评分衍生的整体评分（r=0.77，n=282）均具有强烈的、具有统计学意义的相关性（P＜0.001）。该测量方法的可接受性、反应性和下限或上限效应被认为是充分的。严重程度分级的最佳划分是 1、21 和 87（κ=0.4902）。
该患者队列仅来自西北太平洋地区的三级护理诊所，且缺乏种族多样性。
本研究结果表明，SGA×BSA 是一种在临床实践中评估特应性皮炎体征的有效且可行的工具。
