特应性皮炎成人患者报告结局测量信息系统全球健康量表的有效性和信度。
Validity and reliability of Patient-Reported Outcomes Measurement Information System Global Health scale in adults with atopic dermatitis.
机构信息
Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois.
出版信息
J Am Acad Dermatol. 2021 Sep;85(3):636-644. doi: 10.1016/j.jaad.2021.01.033. Epub 2021 Jan 20.
BACKGROUND
Patient-Reported Outcomes Measurement Information System Global Health (PGH) was validated to assess health-related quality of life in several diseases. Little is known about its measurement properties in adult atopic dermatitis.
OBJECTIVE
Examine the measurement properties of PGH in adult atopic dermatitis.
METHODS
A prospective dermatology practice-based study of 994 atopic dermatitis patients (18-97 years).
RESULTS
PGH physical and mental health 4-item and abridged 2-item T scores, as well as mapped EuroQol-5D score, showed strong to very strong correlation with one another and moderate to strong Spearman correlations with Patient-Oriented Scoring Atopic Dermatitis, Patient-Health Questionnaire-9, Patient-Reported Outcomes Measurement Information System sleep disturbance and related impairment, Eczema Area and Severity Index, objective Scoring Atopic Dermatitis; and weak to moderate correlations with Patient Oriented Eczema Measure, numeric rating scale worst itch and average itch, and Scoring Atopic Dermatitis. The Dermatology Life Quality Index (DLQI) had stronger correlations with Patient Oriented Eczema Measure, Patient-Oriented Scoring Atopic Dermatitis, numeric rating scale worst itch and average itch, Eczema Area and Severity Index, and Scoring Atopic Dermatitis, but weaker correlations with Patient-Health Questionnaire-9 and Patient-Reported Outcomes Measurement Information System sleep disturbance and related impairment (convergent/divergent validity). PGH and DLQI scores had similarly poor ability to differentiate between levels of self-reported global atopic dermatitis severity (known-groups validity). No floor or ceiling effects were observed. No PGH or DLQI items had differential item functioning by demographics. PGH and DLQI scores showed fair to good responsiveness. Finally, PGH and DLQI showed similarly good test-retest reliability.
LIMITATIONS
Single-center study.
CONCLUSION
PGH scores had sufficient validity and reliability to assess health-related quality of life in atopic dermatitis.
背景
患者报告结局测量信息系统全球健康量表（PGH）已被验证可用于评估多种疾病的健康相关生活质量。但对于成人特应性皮炎患者，其测量特性知之甚少。
目的
评估 PGH 在成人特应性皮炎中的测量特性。
方法
一项前瞻性的皮肤科实践基础研究，纳入 994 例特应性皮炎患者（18-97 岁）。
结果
PGH 物理和心理健康 4 项和简版 2 项 T 评分，以及映射的 EuroQol-5D 评分，彼此之间具有很强到非常强的相关性，与患者导向的特应性皮炎评分、患者健康问卷-9、患者报告的结局测量信息系统睡眠障碍及其相关损害、湿疹面积和严重程度指数、客观特应性皮炎评分具有中度到很强的斯皮尔曼相关性；与患者导向的特应性皮炎量表、数字评分量表最严重瘙痒和平均瘙痒、特应性皮炎评分的相关性较弱。皮肤病生活质量指数（DLQI）与患者导向的特应性皮炎量表、患者导向的特应性皮炎评分、数字评分量表最严重瘙痒和平均瘙痒、湿疹面积和严重程度指数、特应性皮炎评分的相关性更强，与患者健康问卷-9 和患者报告的结局测量信息系统睡眠障碍及其相关损害的相关性更弱（会聚/发散有效性）。PGH 和 DLQI 评分区分自我报告的特应性皮炎严重程度的能力相似（已知组有效性）。未观察到地板或天花板效应。PGH 和 DLQI 无项目具有按人口统计学差异的项目功能。PGH 和 DLQI 评分具有良好的反应度。最后，PGH 和 DLQI 显示出相似的良好测试-重测信度。
局限性
单中心研究。
结论
PGH 评分具有足够的有效性和可靠性，可用于评估特应性皮炎患者的健康相关生活质量。
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