Gala Khushboo, Guardiola-Bright John, McGee Suzanne
Internal Medicine, University of Louisville Hospital, Louisville, USA.
Internal Medicine, University of Louisville, Louisville, USA.
Cureus. 2020 Apr 20;12(4):e7750. doi: 10.7759/cureus.7750.
Transarterial chemoembolization (TACE) is a generally well-tolerated and safe procedure that is increasingly being used in the management of intermediate-stage hepatocellular carcinoma (HCC). Tumor rupture is a rare major complication of TACE. Predisposing factors for tumor rupture include large tumor size and peripherally located tumors; in cases of HCC in cirrhosis secondary to autoimmune hepatitis (AIH), tumor rupture may occur more frequently because of the phenomenon of peliosis that occurs in AIH leading to higher propensity to rupture. Management of tumor rupture can be surgical or conservative depending on the individual case. We describe the first documented case of tumor rupture post-TACE in a patient with AIH cirrhosis and HCC.
经动脉化疗栓塞术（TACE）是一种耐受性良好且安全的手术，越来越多地用于中期肝细胞癌（HCC）的治疗。肿瘤破裂是TACE罕见的严重并发症。肿瘤破裂的诱发因素包括肿瘤体积大及肿瘤位于周边；在自身免疫性肝炎（AIH）继发肝硬化的HCC病例中，由于AIH中发生的紫癜现象导致更高的破裂倾向，肿瘤破裂可能更频繁发生。根据具体病例，肿瘤破裂的处理可以是手术治疗或保守治疗。我们描述了首例有记录的AIH肝硬化合并HCC患者TACE术后肿瘤破裂的病例。
