[台湾原生药材对实验性肝损伤的保护作用]

[Protective effects of Taiwan crude drugs on experimental liver injuries].

作者信息

Ohta S, Sato N, Tu S H, Shinoda M

机构信息

Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

出版信息

Yakugaku Zasshi. 1993 Dec;113(12):870-80. doi: 10.1248/yakushi1947.113.12_870.

DOI:10.1248/yakushi1947.113.12_870

PMID:8301540

Abstract

Protective effects of 41 Taiwan crude drugs on rat hepatic injuries caused by carbon tetrachloride (CCl4) and alpha-naphthylisothiocyanate (ANIT) were investigated. The methanol extracts of Elephantopi Herba and Lonicerae Flos inhibited the release of intrahepatic enzymes and histological changes by CCl4. The methanol extracts of Canarii Radix, Arecae Pericarpium, Cynomorii Caulis, Polygoni Cuspidati Radix, Phyllodii Herba, Junci Caulis Medulla, Rubiae Herba and Rhinacanthi Herba protected the hepatic injury by ANIT. Among them, the water extracts of Cymorii Caulis and Junci Caulis Medulla showed higher protective potency than the methanol extracts. And them this two crude drugs also protected the cholestasis by ANIT.

摘要

研究了41种台湾生药对四氯化碳（CCl4）和α-萘异硫氰酸酯（ANIT）所致大鼠肝损伤的保护作用。土木香和金银花的甲醇提取物可抑制CCl4诱导的肝内酶释放和组织学变化。橄榄根、槟榔果皮、锁阳茎、虎杖根、叶下珠、灯心草髓、茜草和青牛胆的甲醇提取物对ANIT所致肝损伤具有保护作用。其中，锁阳茎和灯心草髓的水提取物比甲醇提取物具有更高的保护效力。并且这两种生药还对ANIT所致胆汁淤积具有保护作用。