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IBD 微生物代谢组：好、坏和未知。

IBD Microbial Metabolome: The Good, Bad, and Unknown.

机构信息

Department of Medicine, University of Chicago, Chicago, IL, USA.

Department of Medicine, University of Chicago, Chicago, IL, USA.

出版信息

Trends Endocrinol Metab. 2020 Nov;31(11):807-809. doi: 10.1016/j.tem.2020.05.001. Epub 2020 May 23.

DOI:10.1016/j.tem.2020.05.001
PMID:32456844
Abstract

Gut microbiota shape the metabolome which then directly impacts host physiology. Sinha et al. observe and suggest that decreases in the levels of Ruminococcaceae and secondary bile acids (SBAs) contribute to pouchitis in ulcerative colitis (UC) patients with ileal pouch anal anastomosis (IPAA), raising the possibility of using SBAs as a preventative measure.

摘要

肠道微生物群塑造了代谢组，进而直接影响宿主生理。Sinha 等人观察到并提出，在患有回肠贮袋肛管吻合术（IPAA）的溃疡性结肠炎（UC）患者中，厚壁菌门和次级胆汁酸（SBA）水平的降低导致贮袋炎，这增加了使用 SBA 作为预防措施的可能性。

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