通过改变微生物谱治疗和预防急慢性袋炎的最佳方法。
Optimal Approaches to Treating and Preventing Acute and Chronic Pouchitis by Altering Microbial Profiles.
作者信息
Kallumkal Govind, Barnes Edward L
机构信息
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Multidisciplinary Center for Inflammatory Bowel Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
出版信息
Gastroenterol Clin North Am. 2025 Jun;54(2):469-483. doi: 10.1016/j.gtc.2024.12.007. Epub 2025 Jan 9.
Pouchitis is the most common complication after restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. The authors review the role of the microbiota in both the pathogenesis of pouchitis, primarily via dysbiosis, as well as the resultant treatment strategies focused on correcting dysbiosis among patients with pouchitis. These include the role of antibiotics, probiotics, and potentially metabolomics in both treatment and risk stratification.
袋炎是溃疡性结肠炎行回肠储袋肛管吻合术的全直肠系膜切除术后最常见的并发症。作者回顾了微生物群在袋炎发病机制中的作用，主要是通过生态失调，以及针对袋炎患者纠正生态失调的治疗策略。这些包括抗生素、益生菌以及代谢组学在治疗和风险分层中的作用。
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