Department of Obstetrics and Gynhaecology, University of Melbourne and Gynaecology Research Centre, Level 7, Cnr Grattan St and Flemington Rd, Royal Women's Hospital, Parkville, Victoria 3052, Australia.
Melbourne Bioinformatics, University of Melbourne, 187 Grattan Street, Carlton, Victoria 3053, Australia.
Reprod Biomed Online. 2020 Jul;41(1):113-118. doi: 10.1016/j.rbmo.2020.03.015. Epub 2020 May 3.
Does obesity affect endometrial gene expression in women with endometriosis, specifically women with stage I disease?
Differential gene expression analysis was conducted on endometrium from women with and without endometriosis (n = 169). Women were diagnosed after surgical visualization and staged according to the revised American Society for Reproductive Medicine (stage I-IV). Women were grouped by body mass index (BMI) (kg/m) as underweight, normal, pre-obese or obese. After accounting for menstrual cycle stage, endometrial gene expression was analysed by BMI (continuous and grouped) in women with endometriosis, and in non-endometriosis controls.
No significant interaction effect was found between BMI and endometriosis status on endometrial gene expression. We have previously reported that obese women with endometriosis have a reduced incidence of stage I disease; however, stratifying our analysis into stage I endometriosis versus combined II, III and IV endometriosis failed to reveal any differentially expressed endometrial genes between normal, pre-obese and obese patients.
Despite obesity having deleterious effects on endometrial gene expression in other gynaecological pathologies, e.g. endometrial cancer and polycystic ovary syndrome, our results do not support an association between BMI and altered endometrial gene expression in women with or without endometriosis.
肥胖是否会影响子宫内膜异位症患者（尤其是 I 期疾病患者）的子宫内膜基因表达？
对子宫内膜异位症患者（n=169）和非子宫内膜异位症患者的子宫内膜进行差异基因表达分析。通过手术可视化和根据修订后的美国生殖医学学会（I-IV 期）分期对女性进行诊断。根据体重指数（BMI）（kg/m）将女性分为消瘦、正常、超重或肥胖。在考虑到月经周期阶段后，通过 BMI（连续和分组）分析子宫内膜基因表达，包括子宫内膜异位症患者和非子宫内膜异位症对照组。
BMI 和子宫内膜异位症状态对子宫内膜基因表达没有显著的交互作用。我们之前曾报道过肥胖的子宫内膜异位症患者 I 期疾病的发病率降低；然而，将我们的分析分为 I 期子宫内膜异位症与 II、III 和 IV 期子宫内膜异位症相结合，未能发现正常、超重和肥胖患者之间存在任何差异表达的子宫内膜基因。
尽管肥胖对其他妇科疾病（如子宫内膜癌和多囊卵巢综合征）的子宫内膜基因表达有不良影响，但我们的结果不支持 BMI 与子宫内膜异位症患者或非子宫内膜异位症患者的子宫内膜基因表达改变之间存在关联。
