Knapp C C, Sierra-Madero J, Washington J A
Department of Microbiology, Cleveland Clinic Foundation, Ohio 44195.
Antimicrob Agents Chemother. 1988 Dec;32(12):1896-8. doi: 10.1128/AAC.32.12.1896.
Cefpodoxime, cefixime, and ceftriaxone inhibited Branhamella catarrhalis at less than or equal to 1 microgram/ml, beta-hemolytic streptococci at less than or equal to 0.25 microgram/ml, Neisseria meningitidis at less than or equal to 0.06 microgram/ml, and Haemophilus influenzae (other than beta-lactamase-negative, ampicillin-resistant isolates) at less than or equal to 0.12 microgram/ml. The MICs for 50% of isolates of the family Enterobacteriaceae other than Citrobacter freundii, Enterobacter aerogenes, and Enterobacter cloacae were less than or equal to 1 microgram/ml for all three cephalosporins. The MICs of each cephalosporin for 90% of staphylococci, enterococci, and Pseudomonas aeruginosa isolates were greater than 16 micrograms/ml. Inoculum effects were noted with cefpodoxime and cefixime with beta-lactamase-positive H. influenzae.
头孢泊肟、头孢克肟和头孢曲松对卡他莫拉菌的抑菌浓度小于或等于1微克/毫升，对β溶血性链球菌的抑菌浓度小于或等于0.25微克/毫升，对脑膜炎奈瑟菌的抑菌浓度小于或等于0.06微克/毫升，对流感嗜血杆菌（β内酰胺酶阴性、氨苄西林耐药菌株除外）的抑菌浓度小于或等于0.12微克/毫升。除弗氏柠檬酸杆菌、产气肠杆菌和阴沟肠杆菌外，三种头孢菌素对50%的肠杆菌科菌株的最低抑菌浓度均小于或等于1微克/毫升。每种头孢菌素对90%的葡萄球菌、肠球菌和铜绿假单胞菌菌株的最低抑菌浓度均大于16微克/毫升。头孢泊肟和头孢克肟对β内酰胺酶阳性流感嗜血杆菌有接种物效应。
