School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
J Mater Chem B. 2020 Jul 7;8(24):5330-5335. doi: 10.1039/c9tb02868d. Epub 2020 May 27.
Size-controlled clustering of iron oxide nanoparticles (IONPs) within the fluorescent polymer nanogels was achieved using the lower critical solution temperature (LCST) driven self-assembly and cross-linking of grafted polymer on the IONPs. The grafted polymer was comprised of oligoethyleneglycol methacrylate (OEGMA) and a novel dichloromaleimide functional methacrylate monomer as building blocks. As a result of the temperature responsive behavior of OEGMA, polymer grafted IONPs clustered to form larger nano-sized aggregates when heated above the LCST of the polymer. When these nano-sized aggregates were cross-linked using an amine-dichloromaleimide reaction, well-defined fluorescent hybrid nanogels could be fabricated. Moreover, the size of these hybrid nanogels was effectively controlled by varying the initial concentration of the polymer grafted IONPs in water.
采用具有较低临界溶液温度（LCST）的接枝聚合物的自组装和交联作用，可在荧光聚合物纳米凝胶内实现氧化铁纳米粒子（IONPs）的尺寸控制聚集。接枝聚合物由聚乙二醇甲基丙烯酸酯（OEGMA）和一种新型二氯马来酰亚胺功能甲基丙烯酸酯单体作为构建块组成。由于 OEGMA 的温度响应特性，当聚合物的 LCST 以上加热时，聚合物接枝的 IONPs 聚集形成更大的纳米级聚集体。当使用胺-二氯马来酰亚胺反应交联这些纳米级聚集体时，可以制备出具有良好定义的荧光杂化纳米凝胶。此外，通过改变水中接枝聚合物的 IONPs 的初始浓度，可以有效地控制这些杂化纳米凝胶的尺寸。
