Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30322, United States.
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, Shanghai 200240, China.
Nano Lett. 2020 Apr 8;20(4):2799-2805. doi: 10.1021/acs.nanolett.0c00484. Epub 2020 Mar 30.
Magnetic iron oxide nanoparticles (IONPs) have received significant interest for the use in biomedical applications. The assembly of IONPs into larger superstructures has been used to modify the properties and functionality of these particles. For example, the clustering of IONPs can lead to improvements in MRI contrast generation, changes in heat generation during magnetic fluid hyperthermia, and alterations to pharmacokinetics and biodistribution. Nevertheless, the IONP clustering leads to significant heterogeneity in the assembly. Here, we demonstrate a method for using DNA origami to precisely control the number and positions of IONPs. We also showed how this technique can be used to module the functionality of IONP clusters by showing how MRI contrast generation efficiency can be tuned by altering the number and spacing of IONPs. Finally, we show that these property changes can be dynamically regulated, demonstrating the possibility for this technology to be used in biosensing applications.
磁性氧化铁纳米粒子（IONPs）在生物医学应用中受到了广泛关注。将 IONPs 组装成更大的超结构已被用于修饰这些粒子的性质和功能。例如，IONPs 的聚集可以提高 MRI 对比生成的效率，改变磁流体热疗过程中的产热量，并改变药代动力学和生物分布。然而，IONP 的聚集会导致组装的显著异质性。在这里，我们展示了一种使用 DNA 折纸术精确控制 IONP 数量和位置的方法。我们还展示了如何通过改变 IONP 的数量和间距来调整 MRI 对比生成效率，从而利用该技术来调整 IONP 簇的功能。最后，我们表明这些性质的变化可以动态调节，这表明该技术有可能用于生物传感应用。
