Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
J Infect Dis. 2020 Oct 13;222(10):1723-1730. doi: 10.1093/infdis/jiaa288.
While mother-to-child transmission is believed to play in important role in early childhood infection with Kaposi sarcoma-associated herpesvirus (KSHV), the maternal immune response remains largely uncharacterized. This study aimed to characterize the longitudinal humoral response to KSHV in a cohort of HIV-infected Zambian mothers without KS and identify potential factors that may influence transmission. In total, 86/124 (69.4%) mothers were found to be KSHV seropositive. Longitudinal KSHV titers were fairly stable over time, although seroreversion was still common. Of the total 124 mothers, 81 had at least 1 child KSHV seroconvert during the 2 years analyzed, while the remaining 43 mothers had KSHV-seronegative children. Mothers of KSHV-negative children had higher geometric mean titers than mothers of KSHV-positive children; however, there was no difference in the presence of neutralizing antibodies. This suggests that a strong anti-KSHV immune response, and potentially nonneutralizing antibodies, may reduce transmission.
虽然人们认为母婴传播在儿童时期卡波氏肉瘤相关疱疹病毒（KSHV）感染中起着重要作用，但母体的免疫反应在很大程度上仍未得到充分描述。本研究旨在描述感染 HIV 的赞比亚母亲中无卡波氏肉瘤的队列中，针对 KSHV 的纵向体液反应，并确定可能影响传播的潜在因素。共有 124 名母亲中的 86 名（69.4%）被发现为 KSHV 血清阳性。尽管血清学转换仍然很常见，但 KSHV 滴度随时间的纵向变化相当稳定。在分析的 2 年内，总共 124 名母亲中有 81 名至少有 1 名子女 KSHV 血清转化，而其余 43 名母亲的子女 KSHV 血清阴性。KSHV 阴性儿童的母亲的几何平均滴度高于 KSHV 阳性儿童的母亲；然而，中和抗体的存在没有差异。这表明强大的抗 KSHV 免疫反应，以及潜在的非中和抗体，可能会降低传播。
