Centre for Natural Products & Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500 007, Telangana, India.
Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500 007, Telangana India.
J Agric Food Chem. 2020 Jun 24;68(25):6826-6834. doi: 10.1021/acs.jafc.0c00862. Epub 2020 Jun 10.
UPLC-MS guided isolation of CHCl extract from the fruits of yielded two new mexicanolide-type limonoids trichanolide F () and trichanolide G () along with a known compound carapanolide U (). The structures of the limonoids were characterized by extensive spectroscopic analysis (MS, IR, 2D NMR). These limonoids (-) were evaluated for their antifeedancy against F. To further explore and draw the meaningful structure activity relationship studies, secophragmalin-type limonoids, namely, secotrichagmalin B, C (, ) and semisynthetic derivatives (-) were also screened for antifeedancy. The results revealed that trichanolide F () displayed highest antifeedant index (AFI) and caused larval mortality at 24 h. Derivative caused larval toxicity, whereas , , , and lead to pupal mortality and , , , and caused adult deformities. Overall, the study provided new insights into the antifeedant potential of isolated and chemically modified limonoids from for the control of spodopteran pests.
超高效液相色谱-质谱联用指导从果实中分离出的 CHCl3 提取物，得到了两种新的墨西哥内酯型柠檬苦素化合物： Trichanolide F () 和 Trichanolide G ()，以及一种已知化合物 Carapanolide U ()。通过广泛的光谱分析（MS、IR、2D NMR）对柠檬苦素的结构进行了表征。对这些柠檬苦素（-）进行了抗食活性评估，以对抗 F. 为了进一步探索和绘制有意义的构效关系研究，还筛选了 secophragmalin 型柠檬苦素，即 secotrichagmalin B、C（，）和半合成衍生物（-）的抗食活性。结果表明， Trichanolide F () 表现出最高的抗食活性指数（AFI），并在 24 小时内导致幼虫死亡。衍生物 导致幼虫毒性，而 ， ， ， 和 导致蛹死亡， ， ， 和 导致成虫畸形。总体而言，该研究为控制鳞翅目害虫提供了从 中分离和化学修饰的柠檬苦素的抗食潜力的新见解。
