The American Society for Parenteral and Enteral Nutrition, Silver Spring, Maryland, USA.
College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Nutr Clin Pract. 2020 Oct;35(5):769-782. doi: 10.1002/ncp.10496. Epub 2020 May 27.
Lipid injectable emulsions (ILEs) are complex pharmaceutical formulations used as a source of energy and essential fatty acids in parenteral nutrition. Issues associated with ILE use are distinctly different from oral fat and arise from emulsion stability, dose, and infusion tolerance. Since 1975, soybean oil has been the consistent source oil used in ILE formulations in the US. Partly because of safety concerns with the soybean-based ILE and frequent and long-standing problems with product inventory shortages, new ILE products have become available. Gaps in ILE best practices create a risk for ILE safety errors in prescribing, compounding, and administration of these products. This paper provides information on appropriate indications, dosing, and methods to avoid potential errors with ILE products in the US. This paper (Part 1) will focus on ILE background, information, and recommendations for adult patients, whereas Part 2 of this series will focus on neonatal and pediatric patient-specific information.
脂溶性注射用乳剂（ILE）是一种复杂的药物制剂，用作肠外营养的能量和必需脂肪酸来源。ILE 使用相关问题与口服脂肪明显不同，主要源于乳剂的稳定性、剂量和输注耐受性。自 1975 年以来，大豆油一直是美国 ILE 配方中使用的常规油源。部分由于基于大豆的 ILE 安全性问题以及产品库存短缺的频繁和长期存在问题，新的 ILE 产品已经上市。ILE 最佳实践中的差距导致在处方、配制和管理这些产品时存在 ILE 安全性错误的风险。本文提供了有关在美国使用 ILE 产品的适当适应证、剂量和避免潜在错误的方法的信息。本文（第 1 部分）将重点介绍 ILE 的背景、信息和成人患者的建议，而本系列的第 2 部分将重点介绍新生儿和儿科患者的具体信息。
