Research Institute of Clinical Nutrition, Kyung Hee University, Seoul, Republic of Korea.
Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation, Daejeon, Republic of Korea.
J Med Food. 2020 Jul;23(7):735-744. doi: 10.1089/jmf.2019.4555. Epub 2020 May 27.
Estrogen, produced mainly in the ovaries, plays a role in sexual development, metabolism, and bone formation. Thus, estrogen deficiency due to menopause can lead to overweight, dyslipidemia, and osteoporosis. In this study, we compared the effects of extracts of , , and their mixtures at various ratios on osteosarcoma SaOS-2 cells and investigated the effect of PS31 (: = 3:1, KGC02PS) on postmenopausal symptoms in ovariectomized rats. PS31 supplementation, as little as 100 mg/kg BW, effectively reduced ovariectomy-induced weight gain, and total triglyceride, total cholesterol, and low-density lipoprotein-cholesterol concentrations in serum. In addition, PS31 supplementation prevented bone density loss, inhibited bone resorption, and reduced the expression of catabolic factors in bone. However, PS31 supplementation did not affect uterus weight and expression of c-Jun and c-Fos, which suggests that the mechanism of action of PS31 is distinct from that of estrogen. Taken together, we demonstrated that PS31 supplementation alleviated postmenopausal symptoms, including overweight, dyslipidemia, and osteoporosis. Therefore, PS31 could be potentially used as food supplement to prevent postmenopausal symptoms.
雌激素主要由卵巢产生，在性发育、新陈代谢和骨骼形成中发挥作用。因此，由于绝经导致的雌激素缺乏会导致超重、血脂异常和骨质疏松。在这项研究中，我们比较了 、 和它们以不同比例混合的提取物对骨肉瘤 SaOS-2 细胞的影响，并研究了 PS31（： = 3:1，KGC02PS）对去卵巢大鼠绝经后症状的影响。PS31 补充剂，低至 100mg/kg BW，可有效减少去卵巢引起的体重增加，以及血清中总甘油三酯、总胆固醇和低密度脂蛋白胆固醇浓度。此外，PS31 补充剂可防止骨密度丢失，抑制骨吸收，并降低骨中分解代谢因子的表达。然而，PS31 补充剂对子宫重量和 c-Jun 和 c-Fos 的表达没有影响，这表明 PS31 的作用机制与雌激素不同。综上所述，我们证明了 PS31 补充剂可缓解绝经后症状，包括超重、血脂异常和骨质疏松症。因此，PS31 可作为预防绝经后症状的膳食补充剂使用。
