College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Republic of Korea.
Anydoctor Healthcare Co., Ltd., Cheonan, Republic of Korea.
Evid Based Complement Alternat Med. 2018 Feb 12;2018:2929107. doi: 10.1155/2018/2929107. eCollection 2018.
In order to assess the effectiveness of a hop extract (HE) for postmenopausal symptoms, the effects of Lifenol on ovariectomy-induced osteoporosis, hyperlipidemia, body weight increase, and hot flash were investigated in rats.
Female Sprague-Dawley rats were ovariectomized and subjected to a daily scheduled exercise training (15 min at 15 m/min) or treated with HE (30 or 100 mg/kg, oral) or 17-estradiol (100 g/kg, intraperitoneal) for 12 weeks. Body and visceral fat weights, serum lipid profiles, osteoporotic parameters in serum, and femoral bones were analyzed. Separately, forced running-induced dermal and rectal temperatures and blood flow velocity were measured in ovariectomized rats.
Ovariectomy increased blood lipids including triglycerides, total cholesterol, and low-density lipoproteins, leading to visceral fat accumulation and overweight. Estrogen depletion caused osteoporosis, displaying decreased femoral bone weight, bone mineral density and content, and blood phosphorus level. The disturbances in lipid metabolism and bone resorption were recovered by treatment with HE in a dose-dependent manner. In addition, HE treatment shortened the duration of forced running-induced alterations in skin and rectal temperatures by reducing blood flow velocity.
The results indicate that HE attenuated overweight, osteoporosis, and hot flash in estrogen-deficient animals by regulating blood lipid profile and fat accumulation, blood estrogen and bone resorption factors, and dermal blood flow.
为了评估葎草属植物提取物（HE）对绝经后症状的有效性，研究了 Lifenol 对去卵巢诱导的骨质疏松症、高血脂、体重增加和热潮红的影响。
雌性 Sprague-Dawley 大鼠去卵巢，并进行每日定时运动训练（15 分钟，15 m/min）或用 HE（30 或 100mg/kg，口服）或 17-β雌二醇（100μg/kg，腹腔内注射）治疗 12 周。分析体脂和内脏脂肪重量、血清脂质谱、血清骨质疏松参数和股骨骨密度。分别测量去卵巢大鼠强迫跑步引起的皮肤和直肠温度以及血流速度。
去卵巢增加了包括甘油三酯、总胆固醇和低密度脂蛋白在内的血液脂质，导致内脏脂肪堆积和超重。雌激素耗竭导致骨质疏松症，表现为股骨重量、骨矿物质密度和含量以及血磷水平下降。HE 以剂量依赖性方式治疗可恢复脂质代谢和骨吸收的紊乱。此外，HE 治疗通过降低血流速度缩短了强迫跑步引起的皮肤和直肠温度变化的持续时间。
结果表明，HE 通过调节血脂谱和脂肪堆积、血液雌激素和骨吸收因子以及皮肤血流来减轻去势动物的超重、骨质疏松症和热潮红。
