Ferreira Marina, Zacaron Luciana Helena, Valle Annair Freitas do, Gamonal Aloisio Carlos Couri
University Hospital, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
University Hospital, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
An Bras Dermatol. 2020 Jul-Aug;95(4):469-472. doi: 10.1016/j.abd.2019.02.007. Epub 2019 Nov 25.
Localized pretibial myxedema is a dermopathy whose treatment is a challenge in dermatology, occurring in 0.5-4% of patients with Graves' disease. This autoimmune thyroid condition stimulates the production of hyaluronic acid and glycosaminoglycans that are deposited particularly in the pretibial region. Clinically, it presents as a localized, circumscribed, and non-depressible infiltrate in plaques. Several treatment modalities have been proposed, and their results vary, with worse response observed in severe cases. This report presents the case of a patient with elephantiasic pretibial myxedema who was subjected to intralesional corticosteroid applications, resulting in an excellent and encouraging therapeutic response that was maintained.
局限性胫前黏液性水肿是一种皮肤病，其治疗在皮肤科领域颇具挑战，在0.5%至4%的格雷夫斯病患者中出现。这种自身免疫性甲状腺疾病会刺激透明质酸和糖胺聚糖的产生，这些物质尤其沉积在胫前区域。临床上，它表现为斑块状的局限性、边界清晰且不可凹陷的浸润。已经提出了几种治疗方式，其效果各不相同，严重病例的反应较差。本报告介绍了一例患有象皮病样胫前黏液性水肿的患者，该患者接受了皮损内注射皮质类固醇治疗，取得了极佳且令人鼓舞的治疗效果，且效果得以维持。
