Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Org Lett. 2017 Feb 3;19(3):436-439. doi: 10.1021/acs.orglett.6b03448. Epub 2017 Jan 12.
Utilizing photoredox/nickel dual catalysis, diverse flavanones have been synthesized by coupling novel 2-trifluoroboratochromanone building blocks with aryl and heteroaryl bromide partners. The newly reported trifluoroboratochromanones can be easily accessed from the corresponding chromones on multigram scale. This represents a general route for accessing natural and unnatural flavanones that were previously formed through a synthetically more restrictive ring closure route from chalcone precursors.
利用光氧化还原/镍双重催化作用，通过将新型 2-三氟硼基色满酮砌块与芳基和杂芳基溴化物偶联，合成了多种 flavanones。新报道的三氟硼基色满酮可以从相应的色酮在多克规模上很容易获得。这代表了一种获得天然和非天然 flavanones 的一般途径，这些化合物以前是通过从查尔酮前体合成上更具限制性的环合途径形成的。
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