School of Pharmacy, Institutes of Integrative Medicine, Fudan University, Shanghai 201203, P.R. China.
Key Laboratory for Special Functional Materials of the Ministry of Education, School of Materials Science and Engineering, Henan University, Kaifeng 475004, P.R. China.
Org Lett. 2020 Jun 5;22(11):4413-4417. doi: 10.1021/acs.orglett.0c01414. Epub 2020 May 28.
Fluorescent dyes are extensively utilized in various fluorescence imaging techniques. However, many existing modification strategies could not balance the performance (such as brightness, photostability, water solubility, and permeability) of fluorophores. Herein we report a general strategy to enhance the performance of donor-acceptor-type fluorophores by introducing azetidine-containing heterospirocycles to the commonly used fluorophore scaffolds. Such a strategy turned out to be a general way to develop high-quality fluorophores.
荧光染料在各种荧光成像技术中得到了广泛的应用。然而，许多现有的修饰策略不能平衡荧光团的性能（如亮度、光稳定性、水溶性和透过性）。在此，我们报告了一种通过在常用的荧光团骨架中引入含氮杂环丁烷的杂螺环来增强供体-受体型荧光团性能的一般策略。事实证明，这种策略是开发高质量荧光团的一种通用方法。
