Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.
Chem Commun (Camb). 2020 Jun 18;56(49):6624-6627. doi: 10.1039/d0cc01848a.
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
一种新的双靶向聚合物 siRNA 纳米颗粒（Dual-PSNP）通过多种工艺开发而成：滚环转录、缩合、静电沉积和点击化学。通过两种配体的受体介导相互作用的累加，Dual-PSNP 表现出显著改善的癌症特异性细胞内递药、基因敲低功效和凋亡介导的细胞毒性。
