区域和立体选择性 Pd 催化合成 C2-芳基糖苷。
Regio- and diastereoselective Pd-catalyzed synthesis of C2-aryl glycosides.
机构信息
Universite Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France.
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Universite Paris-Saclay, avenue de la terrasse, 91198 Gif-sur-Yvette, France.
出版信息
Chem Commun (Camb). 2020 Jun 30;56(52):7175-7178. doi: 10.1039/d0cc02175j.
PMID:32463030
Abstract
An efficient regio- and diastereoselective arylation method of readily available 2,3-glycals with various aryl iodides has been established. Using the Pd(OAc)2/AsPh3 precatalytic system, this protocol proved to be general to prepare a variety of substituted C2-aryl glycosides in good yields with complete diastereoselectivity.
摘要
一种高效的、区域和立体选择性的芳基化方法，用于各种芳基碘化物与易得的 2,3- 甘油醛的反应已经建立。使用 Pd(OAc)2/AsPh3 预催化体系，该方案被证明是通用的，可以在良好的收率和完全的立体选择性下制备各种取代的 C2-芳基糖苷。
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