Jiang Lei, Weist Stefan, Jansat Susanna
Institute of Chemical Research of Catalonia (ICIQ), Av. Paisos Catalans 16, 43007 Tarragona, Spain.
Org Lett. 2009 Apr 2;11(7):1543-6. doi: 10.1021/ol900131q.
Palladium-catalyzed alpha-arylation and vinylation of dioxolane (S,S)-I, easily obtained from (S)-mandelic acid, proceeds with high yields and excellent diastereoselectivity at room temperature employing commercially available P(t-Bu)(3).HBF(4) and Pd(OAc)(2) as a catalytic precursor system. This method displays general utility for a large variety of aryl, heteroaryl, and vinyl bromides.
钯催化的二氧戊环（S,S）-I的α-芳基化和乙烯基化反应，（S,S）-I可轻松由（S）-扁桃酸制得，在室温下使用市售的三（叔丁基）膦四氟硼酸盐和醋酸钯作为催化前体体系，该反应能以高产率和优异的非对映选择性进行。此方法对多种芳基、杂芳基和乙烯基溴化物均具有普遍适用性。
