钙在周期性瘫痪中维持肌肉收缩力的作用。
A role for external Ca2+ in maintaining muscle contractility in periodic paralysis.
机构信息
Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
出版信息
J Gen Physiol. 2020 Jul 6;152(7). doi: 10.1085/jgp.202012615.
Abstract
Calcium gluconate has been empirically administered to hasten recovery of force during an episode of periodic paralysis. By using a genetically engineered mouse model, Uwera and colleagues show that low Ca clearly promotes a loss of force in affected muscle, thereby providing the first evidence for the benefit of maintaining normal Ca levels in this disorder.
摘要
葡萄糖酸钙已被经验性用于加速周期性麻痹发作期间的肌力恢复。Uwera 及其同事使用基因工程小鼠模型表明，低钙明显促进了受影响肌肉的肌力丧失，从而首次为在这种疾病中维持正常钙水平有益提供了证据。
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