Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka State, India.
Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka State, India.
Eur J Pharmacol. 2020 Aug 15;881:173208. doi: 10.1016/j.ejphar.2020.173208. Epub 2020 May 25.
In most retinal diseases, neuronal loss is the main cause of vision loss. Neuroprotection is the alteration of neurons and/or their environment to encourage the survival and function of the neurons, especially in environments that are deleterious to the neuronal health. The area of neuroprotection progresses with a therapeutically-based hope of improving vision and clinical outcomes for patients through the developments in neurotrophic therapy, antioxidative therapy, anti-excitotoxic, anti-ischemic, anti-inflammatory, and anti-apoptotic care. In this review, we summarize the various neuroprotection strategies for the treatment of glaucoma, genetics of glaucoma and the role of various nanoplatforms in the treatment of glaucoma.
在大多数视网膜疾病中，神经元的损失是视力丧失的主要原因。神经保护是改变神经元和/或其环境，以鼓励神经元的存活和功能，特别是在对神经元健康有害的环境中。神经保护领域的进展基于通过神经营养治疗、抗氧化治疗、抗兴奋毒性、抗缺血、抗炎和抗细胞凋亡治疗的发展，为改善患者的视力和临床结果带来治疗性希望。在这篇综述中，我们总结了治疗青光眼的各种神经保护策略、青光眼的遗传学以及各种纳米平台在治疗青光眼方面的作用。
