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不适合的心脏瓣膜假体加剧了风湿性心脏病患者的困境。

Poorly suited heart valve prostheses heighten the plight of patients with rheumatic heart disease.

作者信息

Scherman Jacques, Zilla Peter

机构信息

Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, South Africa.

Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, South Africa.

出版信息

Int J Cardiol. 2020 Nov 1;318:104-114. doi: 10.1016/j.ijcard.2020.05.073. Epub 2020 May 26.

Abstract

Rheumatic heart disease (RHD) still affects more patients globally than degenerative valve disease. The vast majority of these patients live in low- to middle-income countries. Once symptomatic, they will need heart valve surgery. Unfortunately, prosthetic valves perform poorly in these patients given their young age, the high incidence of multi-valve disease, late diagnoses and often challenging socio-economic circumstances. Notwithstanding the fact that better valve designs would ideally be available, ill-informed decision making processes between bioprosthetic and mechanical valves are contributing to the poor results. In the absence of multicentred, randomised clinical trials, comparing the current generations of bioprostheses with mechanical valves across all age groups Western guidelines tend to be uncritically applied. As a consequence, mechanical valves are being implanted into patients who are often not able to deal with anticoagulation while bioprosthetic valves may be overly shunned for fear of reoperations. Almost sixty years after the advent of cardiac surgery heart valve prostheses have eventually undergone improvements and several potentially disruptive developments are on the horizon. Until they materialise, however, choices between contemporary valve prostheses need to be made on the basis of individual risk and life-expectancy rather than an uncritical implementation of guidelines that were derived for very different patients and under distinctly different conditions. Given the fast expansion of cardiac surgery in middle-income countries and a growing number of independently operating centres in low-income countries a critical appraisal of facts underlying the choice of heart valve prostheses for patients with RHD seems opportune.

摘要

全球范围内,风湿性心脏病(RHD)患者的数量仍多于退行性瓣膜病患者。这些患者绝大多数生活在低收入和中等收入国家。一旦出现症状,他们就需要进行心脏瓣膜手术。不幸的是,鉴于这些患者年龄较轻、多瓣膜疾病发病率高、诊断较晚且社会经济状况往往具有挑战性,人工瓣膜在这些患者中的表现不佳。尽管理想情况下会有更好的瓣膜设计,但在生物瓣膜和机械瓣膜之间缺乏充分信息的决策过程导致了不良结果。由于缺乏多中心随机临床试验来比较当前几代生物瓣膜与机械瓣膜在所有年龄组中的情况,西方指南往往被不加批判地应用。结果,机械瓣膜被植入到往往无法应对抗凝治疗的患者体内,而生物瓣膜可能因担心再次手术而被过度回避。在心脏外科手术出现近60年后,心脏瓣膜假体终于有了改进,并且有几个潜在的颠覆性进展即将出现。然而,在这些进展实现之前,当代瓣膜假体之间的选择需要基于个体风险和预期寿命来做出,而不是不加批判地执行针对非常不同的患者和截然不同的条件制定的指南。鉴于心脏外科手术在中等收入国家的快速扩张以及低收入国家中独立运营中心数量的不断增加,对RHD患者心脏瓣膜假体选择背后的事实进行批判性评估似乎恰逢其时。

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